| Title | Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy |
| Authors | Xu, Zeping Wu, Yanqing Wang, Fan Li, Xiaofeng Wang, Ping Li, Yuying Wu, Junnan Li, Yiyang Jiang, Ting Pan, Xindian Zhang, Xie Xie, Longteng Xiao, Jian Liu, Yanlong |
| Affiliation | Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China Wenzhou Univ, Inst Life Sci, Wenzhou, Peoples R China Xinjiang Med Univ, Affiliated Hosp 2, Urumqi, Peoples R China Peking Univ, Beijing Hui Long Guan Hosp, Beijing, Peoples R China Hangzhou Normal Univ, Sch Med, Hangzhou, Peoples R China Li Huili Hosp, Ningbo Med Treatment Ctr, Dept Pharm, Ningbo, Peoples R China Ningbo Fourth Hosp, Dept Infect Dis, Xiangshan, Peoples R China Wenzhou Med Univ, Ctr Hlth Assessment, Wenzhou, Peoples R China |
| Keywords | OXIDATIVE STRESS ER-STRESS EXPRESSION PROTEINS OBESITY PATHWAY MODEL NRF2 |
| Issue Date | 3-Mar-2020 |
| Publisher | FRONTIERS IN PHARMACOLOGY |
| Abstract | Background Type 2 diabetes (T2D) is a metabolic dysfunction disease that causes several complications. Liver injury is one of these that severely affects patients with diabetes. Fibroblast growth factor 1 (FGF1) has glucose-lowering activity and plays a role in modulation of several liver injuries. Nevertheless, the effects and potential mechanisms of FGF1 against diabetes-induced liver injury are unknown. Methods To further investigate the effect of FGF1 on diabetic liver injury, we divided db/db mice into two groups and intraperitoneally (i.p.) injected either with FGF1 at 0.5 mg/kg body weight or saline every other day for 4 weeks. Then body weights were measured. Serum and liver tissues were collected for biochemical and molecular analyses. Results FGF1 significantly reduced blood glucose and ameliorated diabetes-induced liver steatosis, fibrosis, and apoptosis. FGF1 also restored defective hepatic autophagy in db/db mice. Mechanistic investigations showed that diabetes markedly induced oxidative stress and endoplasmic reticulum stress and that FGF1 treatment significantly attenuated these effects. Conclusions FGF1-associated glucose level reduction and amelioration of cellular stress are potential protective effects of FGF1 against diabetes-induced liver injury. |
| URI | http://hdl.handle.net/20.500.11897/587809 |
| ISSN | 1663-9812 |
| DOI | 10.3389/fphar.2020.00052 |
| Indexed | SCI(E) Scopus |
| Appears in Collections: | 北京回龙观医院 |
