| Title | Associations between resting heart rate, hypertension, and stroke: A population-based cross-sectional study |
| Authors | Hu, Lihua Huang, Xiao Zhou, Wei You, Chunjiao Liang, Qian Zhou, Di Li, Juxiang Li, Ping Wu, Yanqing Wu, Qinghua Wang, Zengwu Gao, Runlin Bao, Huihui Cheng, Xiaoshu |
| Affiliation | Nanchang Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Nanchang, Jiangxi, Peoples R China Nanchang Univ, Affiliated Hosp 2, Ctr Prevent & Treatment Cardiovasc Dis, Nanchang, Jiangxi, Peoples R China Nanchang Univ, Affiliated Hosp 2, Jiangxi Key Lab Mol Med, Nanchang, Jiangxi, Peoples R China Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing, Peoples R China Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Div Prevent & Community Hlth, Beijing, Peoples R China Chinese Acad Med Sci, Beijing, Peoples R China Peking Union Med Coll, Fuwai Hosp, Beijing, Peoples R China |
| Keywords | China hypertension resting heart rate stroke |
| Issue Date | 2019 |
| Publisher | JOURNAL OF CLINICAL HYPERTENSION |
| Abstract | Uncertainty remains regarding the association between resting heart rate (RHR) with hypertension and stroke because of limited and inconsistent data. We assessed the association between RHR, hypertension, and stroke. In this cross-sectional study, 14 677 participants from the China Hypertension Survey study were analyzed. The history of stroke was conducted by questionnaires. RHR was measured by the standardized electronic monitors. Multivariate logistic regression analyses were performed to evaluate the association between RHR, hypertension, and stroke. Moreover, a generalized additive model (GAM) and smooth curve fitting (penalized spline method) were conducted to assess the association between RHR and stroke in different status of hypertension. Overall, each 10 beats per minute (bpm) increase in RHR was associated with an 18% increased prevalence of stroke (P = 0.017). Subjects with RHR > 80 bpm were associated with a higher prevalence of stroke (OR = 1.47; 95% CI, 1.08-2.01) compared with those with RHR <= 80 bpm. Similarly, hypertensives had a higher prevalence of stroke than normotensives (OR = 3.76; 95% CI, 2.39-5.92). Hypertensives with RHR > 80 bpm had the highest prevalence of stroke compared with their counterparts (OR = 5.47; 95% CI, 3.13-9.56). The fully adjusted smooth curve fitting presented a linear association between RHR and stroke among participants with hypertension, but almost horizontal association among participants without hypertension. In conclusion, elevated RHR and hypertension were independently and jointly associated with the increased prevalence of stroke. These findings suggested that elevated RHR was associated with increased prevalence of stroke especially among hypertensives. |
| URI | http://hdl.handle.net/20.500.11897/548722 |
| ISSN | 1524-6175 |
| DOI | 10.1111/jch.13529 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
