| Title | Activity-dependent constraints on catecholamine signaling |
| Authors | Li, Li Rana, Akshay N. Li, Esther M. Feng, Jiesi Li, Yulong Bruchas, Michael R. |
| Affiliation | Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA Univ Washington, Ctr Neurobiol Addict Pain & Emot, Seattle, WA 98195 USA Seattle Childrens Res Inst, Seattle, WA 98101 USA Univ Washington, Dept Psychol, Seattle, WA 98105 USA Peking Univ, Sch Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China McGovern Inst Brain Res, PKU IDG, Beijing 100871, Peoples R China Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, New Cornerstone Sci Lab, Beijing 100871, Peoples R China Univ Washington, Dept Bioengn, Seattle, WA 98105 USA Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA |
| Keywords | VESICULAR MONOAMINE TRANSPORTER-2 COERULEUS-NORADRENERGIC SYSTEM READILY RELEASABLE POOL LOCUS-CERULEUS NEURONS DOPAMINE NOREPINEPHRINE NORADRENALINE MODULATION RECEPTORS VESICLES |
| Issue Date | 26-Dec-2023 |
| Publisher | CELL REPORTS |
| Abstract | Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and inter-actions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together, these findings provide a more complete understanding of the inverted-U relationship, offering in-sights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling. |
| URI | http://hdl.handle.net/20.500.11897/694111 |
| ISSN | 2211-1247 |
| DOI | 10.1016/j.celrep.2023.113566 |
| Indexed | SCI(E) |
| Appears in Collections: | 生命科学学院 膜生物学国家重点实验室 前沿交叉学科研究院 |
