| Title | Setting of the tentative epidemiological cut-off values of contezolid for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae and Streptococcus agalactiae |
| Authors | Guo, Yan Han, Renru Zhang, Ge Yang, Qiwen Xue, Feng Li, Yun Zhu, Demei Hu, Fupin |
| Affiliation | Fudan Univ, Huashan Hosp, Inst Antibiot, 12 Middle Wulumuqi Rd, Shanghai 200040, Peoples R China Natl Hlth Commiss, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China Acad Med Sci, Peking Union Med Coll Hosp, Beijing, Peoples R China Peking Univ, Inst Clin Pharmacol, Beijing, Peoples R China |
| Keywords | MRX-I |
| Issue Date | Feb-2023 |
| Publisher | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY |
| Abstract | Objectives To set the tentative epidemiological cut-off values (TECOFFs) of contezolid for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae and Streptococcus agalactiae based on the distributions of inhibition zone diameters and MICs. Methods A total of 1358 non-duplicate clinical isolates of Gram-positive bacteria were collected from the patients across China from 2017 to 2020. The isolates were tested for susceptibility to contezolid and the comparator linezolid by broth microdilution and disc diffusion methods in three microbiology laboratories. The zone diameters and MICs of linezolid WT strains were used to set the WT TECOFFs of contezolid by normalized resistance interpretation calculations. Results Contezolid showed an aggregate MIC range from 0.03 to 8 mg/L and MIC90 value of 1-2 mg/L against all of the Gram-positive bacterial strains tested. The TECOFF of contezolid based on MIC distributions was 4 mg/L for both S. aureus and Enterococcus species, and 2 mg/L for S. pneumoniae and S. agalactiae. The TECOFF of contezolid based on zone diameter was 24 mm for S. aureus, 18 mm for E. faecalis, 20 mm for E. faecium and S. pneumoniae, and 17 mm for S. agalactiae. Conclusions The epidemiological cut-off values of contezolid were set tentatively for selected Gram-positive bacteria using the MIC and zone diameter distributions. These data are helpful for clinical microbiologists and clinicians to interpret the antimicrobial susceptibility results of contezolid. |
| URI | http://hdl.handle.net/20.500.11897/672881 |
| ISSN | 0305-7453 |
| DOI | 10.1093/jac/dkad045 |
| Indexed | SCI(E) |
| Appears in Collections: | 待认领 |
