| Title | Sex differences in residual somatic symptoms in patients with first-episode depression after acute-phase treatment |
| Authors | Shi, Jingjing Wang, Xiaohong Zhao, Na Kang, Chuanyi Yang, Liying Zheng, Yue Liu, Jiacheng Feng, Lei Zhu, Xuequan Ma, Caina Wu, Wenyuan Wang, Gang Hu, Jian |
| Affiliation | Harbin Med Univ, Affiliated Hosp 1, Dept Psychiat, 23 Youzheng St, Harbin 150001, Heilongjiang, Peoples R China Peking Univ, Inst Mental Hlth, Hosp 6, Beijing, Peoples R China Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China Peking Univ, NHC Key Lab Mental Hlth, Beijing, Peoples R China Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China Capital Med Univ, Beijing Key Lab Mental Disorders, Beijing, Peoples R China Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China Harbin First Specialized Hosp, Harbin, Heilongjiang, Peoples R China Tongji Univ, Tongji Hosp, Dept Psychiat, Shanghai, Peoples R China |
| Keywords | QUALITY-OF-LIFE FUNCTIONAL DISABILITY GENDER-DIFFERENCES PHYSICAL SYMPTOMS AMERICAN PATIENTS DISORDER ASSOCIATION PREVALENCE REMISSION ILLNESS |
| Issue Date | 22-Feb-2023 |
| Publisher | BMC PSYCHIATRY |
| Abstract | BackgroundResidual somatic symptoms (RSS) are common in depressed patients, predicting treatment effectiveness. However, sex differences in RSS have received little systematic study. This study was conducted to compare sex differences of RSS in patients with first-episode depression (FED).MethodsNine hundred eighty-two patients with FED were selected and treated for 8 to 12 weeks. We evaluated the subjects' socio-demographic characteristics and residual depressive symptoms. Using the Patient Health Questionnaire-15 (PHQ-15) scale to assess residual somatic symptoms, the Sheehan Disability Scale (SDS) for the assessment of patients' function, the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF) for quality of life.ResultsThe incidence of RSS with FED was 46.4%. For patients with residual symptoms, the age and age of onset in females were higher than males, but males had more years of education than females. The degree of "stomach pain" in females was more severe than in males, while "trouble sleeping" in males was more severe than that in females. Multiple regression analysis showed that the total Q-LES-Q-SF score was an independent influencing factor of RSS in both males and females, while the total SDS score only affected female RSS.ConclusionsThe prevalence of RSS in FED after acute-phase treatment is high. The symptom of "stomachache" is more pronounced in females, while "trouble sleeping" is more severe in males. Quality of life plays an essential role in RSS in both genders. Thus, sex needs to be considered when assessing the relationship between RSS and therapeutic effect in depression. |
| URI | http://hdl.handle.net/20.500.11897/672774 |
| DOI | 10.1186/s12888-023-04612-3 |
| Indexed | SCI(E) |
| Appears in Collections: | 第六医院 |
