| Title | Burden of liver complications related to non-alcoholic fatty liver disease in China from 2005 to 2019: Observations from the Global Burden of Disease Study, 2019 |
| Authors | Liu, Huixin Qi, Jinlei Yang, Jia Liu, Feng Li, Xiaohe Yin, Peng Wang, Lijun Liang, Zhisheng Wei, Lai Rao, Huiying Zhou, Maigeng |
| Affiliation | Peking Univ Peoples Hosp, Dept Clin Epidemiol & Biostat, Beijing, Peoples R China Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pre, Beijing, Peoples R China Peking Univ Peoples Hosp, Peking Univ Hepatol Inst, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing Int Cooperat Base Sci & Technol NAFLD Diag, Beijing, Peoples R China Peking Univ, Sch Publ Hlth, Dept Global Hlth, Beijing, Peoples R China Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Hepatopancreato Biliary Ctr, Sch Clin Med, Beijing, Peoples R China Peking Univ Peoples Hosp, Peking Univ Hepatol Inst, Peking Univ Hlth Sci Ctr, Beijing 100044, Peoples R China Natl Ctr Chron & Noncommunicable Dis Control & Pre, Beijing 100050, Peoples R China |
| Keywords | PREVALENCE RISK SMOKING |
| Issue Date | Mar-2023 |
| Publisher | DIABETES OBESITY & METABOLISM |
| Abstract | Aim: To assess the burden of liver complications related to non-alcoholic fatty liver disease (LC-NAFLD) from 2005 to 2019 in China.Materials and Methods: We used data from the Global Burden of Disease, Injuries, and Risk Factors Study, 2019, to present contemporary and varying profiles of China's LC-NAFLD burden. The Joinpoint Regression model and Gaussian process regression were, respectively, used to estimate the annual percentage change in prevalence rates and disability-adjusted life-year (DALY) rates, and the relationship between the socio-demographic index (SDI) and age-standardized rates of LC-NAFLD.Results: In 2019, China had 293.42 million (95% uncertainty interval [UI]: 263.69-328.44) LC-NAFLD cases with a prevalence rate and DALYs of 20.63 (95% UI: 23.09-18.54) per 1000 people and 591.03 thousand (95% UI: 451.25-737.33), respectively. North China had the highest prevalence but the lowest DALYs of LC-NAFLD, whereas Southwest China had the lowest prevalence but the highest DALYs. LC-NAFLD were more common in men than in women (male: female ratio, 1.27) in 2019. From 2005 to 2019, the prevalence of NAFLD cases increased by 68.32% (from 174.32 million in 2005 to 293.42 million in 2019), mainly because of an age-specific prevalence rate increase.Conclusion: The LC-NAFLD burden in China is substantial and has increased markedly over the past 15 years. Effective measures for low SDI regions and men are needed to address the rapidly increasing NAFLD burden. |
| URI | http://hdl.handle.net/20.500.11897/672217 |
| ISSN | 1462-8902 |
| DOI | 10.1111/dom.15010 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 公共卫生学院 |
