| Title | Live-Cell Glycocalyx Engineering |
| Authors | Li, Yuxin Wang, Mingzhen Hong, Senlian |
| Affiliation | Peking Univ, Chem Biol Ctr, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China |
| Keywords | HEMATOPOIETIC STEM-CELL E-SELECTIN LIGANDS T-CELLS BLOOD-CELLS FUCOSYLATION GLYCOSYLATION GLYCANS TRANSPLANTATION IMMUNOTHERAPY ENGRAFTMENT |
| Issue Date | Feb-2023 |
| Publisher | CHEMBIOCHEM |
| Abstract | A heavy layer of glycans forms a brush matrix bound to the outside of all the cells in our bodies; it is referred to as the "sugar forest" or glycocalyx. Beyond the increased appreciation of the glycocalyx over the past two decades, recent advances in engineering the glycocalyx on live cells have spurred the creation of cellular drugs and novel medical treatments. The development of new tools and techniques has empowered scientists to manipulate the structures and functions of cell-surface glycans on target cells and endow target cells with desired properties. Herein, we provide an overview of live-cell glycocalyx engineering strategies for controlling the cell-surface molecular repertory to suit therapeutic applications, even though the realm of this field remains young and largely unexplored. |
| URI | http://hdl.handle.net/20.500.11897/672035 |
| ISSN | 1439-4227 |
| DOI | 10.1002/cbic.202200707 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 天然药物与仿生药物国家重点实验室 |
