| Title | Improved V delta 2(+) T cells recovery correlates to reduced incidences of mortality and relapse in acute myeloid leukemia after hematopoietic transplantation |
| Authors | Yue, Keli Gao, Haitao Liang, Shuang Wu, Ning Cheng, Cong Xu, Lan-Ping Zhang, Xiao-Hui Wang, Yu Cheng, Yifei Huang, Xiao-Jun Liu, Jiangying |
| Affiliation | Peking Univ, Inst Hematol, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China Natl Clin Res Ctr Hematol Dis, Beijing, Peoples R China Beijing Key Lab Hematopoiet Stem Cell Transplantat, Beijing, Peoples R China Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China |
| Keywords | MINIMAL RESIDUAL DISEASE IMMUNE RECONSTITUTION FREE SURVIVAL DONOR OUTCOMES |
| Issue Date | Feb-2023 |
| Publisher | ANNALS OF HEMATOLOGY |
| Abstract | Acute myeloid leukemia (AML) patients can benefit from allogeneic hematopoietic cell transplantation (alloHCT) and achieve long-term remission. Recovery of T cell quantity and quality is critical to reduce the incidences of life-threatening complications after alloHCT. Although the general recovery level of gamma delta T cells is recognized to be associated with outcomes of patients who suffered from various hematological diseases and received alloHCT, the correlation between gamma delta T cell subsets and the prognosis in AML patients following transplantation remains to be investigated. In the current study, the recoveries of T cell subpopulations in 103 AML patients were dissected at different time points after haploidentical HCT (haploHCT). Statistical analyses showed that the absolute number of V delta 2(+) T cells on day 90 was an independent risk factor for predicting 2-year OS in AML patients following haploHCT. The survival advantage from the improved recovery of day-90 V delta 2(+) T cells was attributed to reducing the infection-related mortality. Consistently, lower 2-year non-relapse mortality was found in recipients with higher day-90 levels of V delta 2(+) T cells. Notably, day-270 V delta 2(+) T cell numbers reversely correlated to both 2-year and 5-year probabilities of relapse in this scenario. These results highlighted the significant correlation of V delta 2(+) T cells recovery with long-term survival and relapse after alloHCT, suggesting that V delta 2(+) T cells-based immune strategies may help control infectious complications and leukemia recurrence in AML patients. |
| URI | http://hdl.handle.net/20.500.11897/671420 |
| ISSN | 0939-5555 |
| DOI | 10.1007/s00277-023-05125-5 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 前沿交叉学科研究院 |
