| Title | Atherosclerosis: The Involvement of Immunity, Cytokines and Cells in Pathogenesis, and Potential Novel Therapeutics |
| Authors | Su, Chang Lu, Yongzheng Wang, Zeyu Guo, Jiacheng Hou, Yachen Wang, Xiaofang Qin, Zhen Gao, Jiamin Sun, Zhaowei Dai, Yichen Liu, Yu Liu, Guozhen Xian, Xunde Cui, Xiaolin Zhang, Jinying Tang, Junnan |
| Affiliation | Zhengzhou Univ, Dept Cardiol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China Key Lab Cardiac Injury & Repair Henan Prov, Zhengzhou, Henan, Peoples R China Henan Prov Clin Res Ctr Cardiovasc Dis, Zhengzhou, Henan, Peoples R China Chinese Univ Hong Kong, Sch Med, Shenzhen, Guangdong, Peoples R China Peking Univ, Inst Cardiovasc Sci, Beijing, Peoples R China |
| Keywords | KILLER T-CELLS MONOCYTE CHEMOATTRACTANT PROTEIN-1 SMOOTH-MUSCLE-CELLS NITRIC-OXIDE ENDOTHELIAL-CELLS OXIDIZED LDL MAST-CELLS IN-VIVO HEMATOPOIETIC STEM ANGIOTENSIN-II |
| Issue Date | Dec-2022 |
| Publisher | AGING AND DISEASE |
| Abstract | As a leading contributor to coronary artery disease (CAD) and stroke, atherosclerosis has become one of the major cardiovascular diseases (CVD) negatively impacting patients worldwide. The endothelial injury is considered to be the initial step of the development of atherosclerosis, resulting in immune cell migration and activation as well as inflammatory factor secretion, which further leads to acute and chronic inflammation. In addition, the inflammation and lipid accumulation at the lesions stimulate specific responses from different types of cells, contributing to the pathological progression of atherosclerosis. As a result, recent studies have focused on using molecular biological approaches such as gene editing and nanotechnology to mediate cellular response during atherosclerotic development for therapeutic purposes. In this review, we systematically discuss inflammatory pathogenesis during the development of atherosclerosis from a cellular level with a focus on the blood cells, including all types of immune cells, together with crucial cells within the blood vessel, such as smooth muscle cells and endothelial cells. In addition, the latest progression of molecular-cellular based therapy for atherosclerosis is also discussed. We hope this review article could be beneficial for the clinical management of atherosclerosis. |
| URI | http://hdl.handle.net/20.500.11897/671187 |
| ISSN | 2152-5250 |
| DOI | 10.14336/AD.2022.1208 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 |
