| Title | Synthesis of pyrimidines from dinitrogen and carbon |
| Authors | Xianghui Shi Qianru Wang Chao Qin Li-Jun Wu Yuanjin Chen Gao-Xiang Wang Yongli Cai Wenbo Gao Teng He Junnian Wei Jianping Guo Ping Chen Zhenfeng Xi |
| Affiliation | Beijing National Laboratory for Molecular Sciences(BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,College of Chemistry,Peking University Dalian Institute of Chemical Physics,Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences |
| Keywords | dinitrogen transformation nitrogen fixation N-C bond formation homogeneous-heterogeneous synergy strategy 15n-labeled pyrimidines |
| Issue Date | 31-Dec-2022 |
| Publisher | National Science Review |
| Abstract | The element nitrogen and nitrogenous compounds are vital to life.The synthesis of nitrogen-containing compounds using dinitrogen as the nitrogen source,not through ammonia,is of great interest and great value but remains a grand challenge.Herein,we describe a strategy to realize this transformation by combining the heterogeneous approach with the homogeneous methodology.The N_2 molecule was first fixed with carbon and LiH through a one-pot heterogeneous process,forming Li_2CN_2 as an 'activated'nitrogen source with high efficiency.Then subsequent homogeneous treatments of Li_2CN_2 to construct the organic synthon carbodiimide and the RNA/DNA building block pyrimidines were fulfilled.By using ~(15)N_2as the feedstock,their corresponding ~(15)N-labeled carbodiimide and pyrimidines were readily obtained.This homogeneous-heterogeneous synergy strategy will open a new chapter for N_2 transformation. |
| URI | http://hdl.handle.net/20.500.11897/669970 |
| ISSN | 2095-5138 |
| DOI | 10.1093/nsr/nwac168 |
| Indexed | SCI(E) 中国科学引文数据库(CSCD) |
| Appears in Collections: | 化学与分子工程学院 北京分子科学国家实验室 生物有机与分子工程教育部重点实验室 |
