| Title | Effects of methionine intake on cognitive function in mild cognitive impairment patients and APP/PS1 Alzheimer?s Disease model mice: Role of the cystathionine-?-synthase/H2S pathway |
| Authors | Xi, Yujia Zhang, Yuyu Zhou, Yiwen Liu, Qing Chen, Xuhui Liu, Xuebo Grune, Tilman Shi, Lin Hou, Min Liu, Zhigang |
| Affiliation | Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling 712100, Shaanxi, Peoples R China Shanghai Jiao Tong Univ, Coll Med, Sch Publ Hlth, Shanghai 200025, Peoples R China Peking Univ, Shenzhen Hosp, Dept Neurol, Shenzhen 518000, Peoples R China German Inst Human Nutr DIfE Potsdam Rehbruecke, Dept Mol Toxicol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xi'an 710119, Shaanxi, Peoples R China Northwest A&F Univ, Shenzhen Res Inst, Shenzhen 518000, Guangdong, Peoples R China |
| Keywords | HYDROGEN-SULFIDE OXIDATIVE STRESS ENDOGENOUS PRODUCTION RESTRICTION DIETARY GLUTATHIONE BETA AGE TOXICITY PROTEIN |
| Issue Date | Feb-2023 |
| Publisher | REDOX BIOLOGY |
| Abstract | As a dietary intervention, methionine restriction (MR) has been reported to increase longevity and improve metabolism disorders. However, the effects of MR on alleviating neurodegenerative diseases such as Alzheimer's disease (AD) are largely unexplored. Here we sought to investigate the neuroprotective effects of low methionine intake in mild cognitive impairment (MCI) patients and APP/PS1 AD model mice, and to uncover the underlying mechanisms. In a cohort composed of 45 individuals diagnosed with MCI and 61 healthy controls without cognitive impairment, methionine intake was found to be positively associated with the increased risk of MCI, where no sex differences were observed. We further conducted a 16-week MR intervention (0.17% methionine, w/w) on APP/PS1 AD model mice. Although MR reduced A beta accumulation in the brain of both male and female APP/PS1 mice, MR improved cognitive function only in male mice, as assessed by the Morris water maze test. Consistently, MR restored synapse ultrastructure and alleviated mitochondrial dysfunction by enhancing mitochondrial biogenesis in the brain of male APP/PS1 mice. Importantly, MR effectively balanced the redox status and activated cystathionine-beta-synthase (CBS)/H2S pathway in the brain of male APP/PS1 mice. Together, our study indicated that lower dietary methionine intake is associated with improved cognitive function, in which CBS/H2S pathway plays an essential role. MR could be a promising nutritional intervention for preventing AD development. |
| URI | http://hdl.handle.net/20.500.11897/669563 |
| ISSN | 2213-2317 |
| DOI | 10.1016/j.redox.2022.102595 |
| Indexed | SCI(E) |
| Appears in Collections: | 深圳医院 |
