| Title | Analysis of Systemic and Serum Risk Factors in Patients with Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy |
| Authors | Tao, Tianchang Xu, Hui Ma, Xiaoyun Cheng, Yong Shi, Xuan Sun, Yaoyao Zhao, Mingwei Huang, Lvzhen Li, Xiaoxin |
| Affiliation | Peking Univ, Eye Dis & Optometry Inst, Dept Ophthalmol, Peoples Hosp, Beijing 100044, Peoples R China Beijing Key Lab Diag & Therapy Retinal & Choroid D, Beijing 100044, Peoples R China Peking Univ, Coll Optometry, Hlth Sci Ctr, Beijing 100044, Peoples R China Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Ophthalmol, Shanghai 201318, Peoples R China Xiamen Univ, Dept Ophthalmol, Xiamen Eye Ctr, Xiamen 361003, Peoples R China |
| Keywords | CORONARY-ARTERY-DISEASE COMPLEMENT FACTOR-H HEMORRHAGE VARIANTS GENE |
| Issue Date | Jan-2023 |
| Publisher | OPHTHALMOLOGY AND THERAPY |
| Abstract | IntroductionIt remains controversial whether polypoidal choroidal vasculopathy (PCV) represents a subtype of neovascular age-related macular degeneration (nAMD) or is a distinct disease entity. This study aimed to compare and analyze systemic and serum risk factors for nAMD and PCV in an aging Chinese population.MethodsA retrospective study was performed on 108 patients with nAMD, 131 patients with PCV, and 219 control subjects. Serum levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), apolipoprotein A1 (APOA1), apolipoprotein B (APOB), complement 3 (C3), and complement 4 (C4) together with data on systemic risk factors, including hyperlipidemia, hypertension, diabetes mellitus (DM), coronary artery disease (CAD), and asthma, were collected. Chi-square tests, independent-samples t tests, and binary logistic regression analyses were performed to evaluate the associations of risk factors with nAMD and PCV.ResultsPatients with PCV and those with nAMD were likely to have hyperlipidemia (P < 0.001). CAD (P = 0.020) and hypertension (P = 0.006) correlated significantly with nAMD and PCV, respectively. Although no association of age and asthma with PCV or nAMD was found (P > 0.05), DM was associated with PCV development (OR = 0.535, P = 0.044). Regarding serum risk factors, HDL, LDL, TG, APOB, and C3 were significantly associated with nAMD (OR < 0.001, P < 0.001; OR = 0.028, P < 0.001; OR = 0.175, P < 0.001; OR = 0.922, P = 0.022; OR < 0.001, P < 0.001) and PCV (OR = 0.001, P = 0.001; OR = 0.097, P = 0.003; OR = 0.410, P = 0.037; OR = 0.895, P = 0.001; OR = 0.001, P < 0.001). Compared with nAMD, higher levels of HDL (P = 0.003) and LDL (P = 0.016) and lower levels of TG (P = 0.039) were found in patients with PCV, but the association of systemic risk factors between the two diseases was not significant (P > 0.05).ConclusionOur findings indicate that hyperlipidemia is significantly associated with both nAMD and PCV. Serum lipid and complement levels have an effect on the pathogenesis of nAMD and PCV, and consideration of the differences between systemic and serum risk factors should be taken into account in clinical management. |
| URI | http://hdl.handle.net/20.500.11897/669474 |
| ISSN | 2193-8245 |
| DOI | 10.1007/s40123-023-00650-y |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
