| Title | The relationship between maternal periconceptional micronutrient supplementation and non-syndromic cleft lip/palate in offspring |
| Authors | Liu, Chunyi Wang, Di Jin, Lei Zhang, Jie Meng, Wenying Shang, Xuejun |
| Affiliation | Peking Univ, Inst Reprod & Child Hlth, Natl Hlth Commiss Key Lab Reprod Hlth, 38 Coll Rd, Beijing, Peoples R China Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China Tongzhou Maternal & Child Hlth Hosp Beijing, Beijing, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Androl, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China Southern Med Univ, Nanjing Sch Clin Med, Nanjing, Peoples R China |
| Keywords | NONSYNDROMIC OROFACIAL CLEFTS ORAL CLEFTS FOLIC-ACID FOLATE STATUS VITAMIN-A RISK EXPOSURE PREVENTION DEFECTS MARKERS |
| Issue Date | Jan-2023 |
| Publisher | BIRTH DEFECTS RESEARCH |
| Abstract | Background: This study aimed to explore the relationship between maternal periconceptional supplementation with folic acid only (FAO) or with multiple micronutrients containing folic acid (MMFA) and non-syndromic cleft lip/palate in offspring. Method: The data came from a prenatal health care system and a birth defects surveillance system in Beijing, China, from 2013 to 2018. Information on maternal FAO/MMFA supplementation was collected by questionnaire in the first trimester, and data on cleft lip/palate were collected at delivery or termination of pregnancy. Inverse probability weighting (IPW) by the propensity score to adjust for the confounders and Poisson regression model was used to estimate risk ratios (RRs) and their 95% confidence intervals (CIs). Results: A total of 63,969 participants were included in the study. Compared to the no-supplementation group, the adjusted RR for the supplementation group was 0.51 (95% CI: 0.40, 0.64). And the adjusted RRs for FAO and MMFA compared to the no-supplementation group were 0.56 (95% CI: 0.40, 0.76) and 0.48 (95% CI: 0.35, 0.65), respectively. Compared to supplement FAO and MMFA with less than 8 days out of 10 days, the adjusted RRs for FAO and MMFA with 8 or more days out of 10 days were 1.17 (95% CI: 0.78, 1.75), and 2.05 (95% CI: 1.37, 3.31), respectively. Conclusion: Maternal supplementation with micronutrients, either FAO or MMFA, during the periconceptional period can reduce the risk for non-syndromic cleft lip/palate in offspring. However, women should be more cautious with MMFA supplementation. |
| URI | http://hdl.handle.net/20.500.11897/668117 |
| ISSN | 2472-1727 |
| DOI | 10.1002/bdr2.2146 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
