| Title | Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions |
| Authors | Heng, Boon Chin Bai, Yunyang Li, Xiaochan Lim, Lee Wei Li, Wang Ge, Zigang Zhang, Xuehui Deng, Xuliang |
| Affiliation | Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China Sunway Univ, Sch Med & Life Sci, Darul Ehsan 47500, Selangor, Malaysia Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China Univ Hong Kong, Li Ka Shing Fac Med, Sch Biomed Sci, Neuromodulat Lab,Pokfulam, Hong Kong, Peoples R China Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R China Peking Univ, Sch & Hosp Stomatol, Dept Dent Mat, Beijing 100081, Peoples R China Peking Univ, Sch & Hosp Stomatol, Dent Med Devices Testing Ctr, Beijing 100081, Peoples R China Peking Univ, Sch & Hosp Stomatol, Natl Engn Res Ctr Oral Biomat & Digital Med Device, NMPA Key Lab Dent Mat,Beijing Lab Biomed Mat, Beijing 100081, Peoples R China Peking Univ, Sch & Hosp Stomatol, Beijing Key Lab Digital Stomatol, Beijing 100081, Peoples R China |
| Keywords | GLYCATION END-PRODUCTS ELECTRICAL-STIMULATION OSTEOGENIC DIFFERENTIATION COMPOSITE SCAFFOLDS MINERAL DENSITY STEM-CELLS OSTEOCLAST DIFFERENTIATION POSTMENOPAUSAL WOMEN TISSUE REGENERATION ANGIOGENIC FACTORS |
| Issue Date | Dec-2022 |
| Publisher | ADVANCED SCIENCE |
| Abstract | Bone degeneration associated with various diseases is increasing due to rapid aging, sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical to bone remodeling, and bone degeneration under various pathological conditions results in significant changes to these bioelectric properties. There is growing interest in utilizing biomimetic electroactive biomaterials that recapitulate the natural electrophysiological microenvironment of healthy bone tissue to promote bone repair. This review first summarizes the etiology of degenerative bone conditions associated with various diseases such as type II diabetes, osteoporosis, periodontitis, osteoarthritis, rheumatoid arthritis, osteomyelitis, and metastatic osteolysis. Next, the diverse array of natural and synthetic electroactive biomaterials with therapeutic potential are discussed. Putative mechanistic pathways by which electroactive biomaterials can mitigate bone degeneration are critically examined, including the enhancement of osteogenesis and angiogenesis, suppression of inflammation and osteoclastogenesis, as well as their anti-bacterial effects. Finally, the limited research on utilization of electroactive biomaterials in the treatment of bone degeneration associated with the aforementioned diseases are examined. Previous studies have mostly focused on using electroactive biomaterials to treat bone traumatic injuries. It is hoped that this review will encourage more research efforts on the use of electroactive biomaterials for treating degenerative bone conditions. |
| URI | http://hdl.handle.net/20.500.11897/660907 |
| DOI | 10.1002/advs.202204502 |
| Indexed | EI SCI(E) |
| Appears in Collections: | 口腔医院 工学院 |
