| Title | Changes in heart rate variability of healthy subjects shortly exposed to printing shop particles and the effect of air purifier intervention |
| Authors | Lyu, Lizhi Xu, Yu Wang, Hongbo Guo, Xin Gao, Yanjun Duan, Shumin Deng, Furong Guo, Xinbiao Wang, Yun |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China Beijing Jishuitan Hosp, Dept Resp Med, Beijing 100035, Peoples R China |
| Keywords | PHOTOCOPIER OPERATORS PARTICULATE MATTER OXIDATIVE STRESS BLACK CARBON COPY CENTER NANOPARTICLES INFLAMMATION ASSOCIATION EXPOSURES CHILDREN |
| Issue Date | 15-Dec-2022 |
| Publisher | ENVIRONMENTAL POLLUTION |
| Abstract | Particulate matter (PM) released by printers may cause airway inflammation and cardiac electrophysiological changes. We conducted a two-stage crossover study to examine the association between short-term exposure to printing shop particles (PSPs) and the heart rate variability (HRV) among healthy volunteers, as well as to evaluate the effect of air purifier intervention. The on-site assessments of PSPs and individual HRV parameters of the volunteers were used to analyze the influence of size-fractionated PSPs and air purifier intervention on HRV at different lag times after PSPs exposure (0 min, 5 min, 15 min, and 30 min) by using the linear mixed-effects models. We observed that changes in 6 HRV parameters were associated with particle mass concentration (PMC) of PSPs, and changes in 8 HRV parameters were associated with particle number concentration (PNC) of PSPs. The sensitive HRV parameters were the square root of the mean of the sum of the squares of differences between adjacent NN intervals (rMSSD), NN50 count divided by the total number of all NN intervals (pNN50), normalized high frequency power (nHF), very high frequency power (VHF), normalized low frequency power (nLF), and the ratio of low frequency power to high frequency power (LF/HF). Most HRV parameters exhibited the strongest effect associated with PMC and PNC at a lag time of 30 min. The air purifier intervention markedly reduced the PNC and PMC of size-fractionated PSPs, enhanced 5 HRV parameters, and decreased the nLF and LF/HF. Our study suggests that short-term exposure to PSPs can affect HRV parameters, reflecting changes in cardiac autonomic nervous activity, and the use of an air purifier can reduce the concentration of PSPs and improve the autonomic nervous system activity of the exposed individuals. |
| URI | http://hdl.handle.net/20.500.11897/659050 |
| ISSN | 0269-7491 |
| DOI | 10.1016/j.envpol.2022.120418 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
