| Title | The association between circulating docosahexaenoic acid and lung cancer: A Mendelian randomization study |
| Authors | Zhao, Hang Wu, Shengnan Luo, Zhenkai Liu, Hailong Sun, Junwei Jin, Xiaolin |
| Affiliation | Peking Univ, China Japan Friendship Sch Clin Med, Beijing, Peoples R China China Japan Friendship Hosp, Yinghuadong Rd, Beijing 100029, Peoples R China China Med Univ, Affiliated Hosp 1, Shenyang, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Dept Colorectal Surg, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China Sun Yat Sen Univ, Affiliated Hosp 1, Dept Joint Surg, Guangzhou, Guangdong, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc, Shenzhen 518116, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Shenzhen Hosp, Shenzhen 518116, Peoples R China China Med Univ, Affiliated Hosp 1, Dept Int Phys Examinat Ctr, Shenyang, Peoples R China |
| Keywords | PHOSPHOLIPID FATTY-ACIDS HEALTH-BENEFITS RECEPTOR-ALPHA TUMOR-GROWTH RISK DHA PLASMA EPIDEMIOLOGY FISH OMEGA-3-FATTY-ACIDS |
| Issue Date | Nov-2022 |
| Publisher | CLINICAL NUTRITION |
| Abstract | Background: Lung cancer is a malignant tumor with a high incidence, it is vital to identify modifiable and avoidable risk factors for primary prevention, which can significantly lower the risk of cancer by preventing exposure to hazards and altering risky behavior. Some observational studies suggest that an increase in docosahexaenoic acid (DHA) consumption can reduce lung cancer risk. However, interpretation of these observational findings is difficult due to residual confounding or reverse causality. To evaluate the link between DHA and lung cancer, we have undertaken this analysis to examine the causal association between DHA and the risk of lung cancer using a two-sample Mendelian randomization (MR) framework. Methods: We performed a two-sample MR analysis to evaluate the causal effect of plasma DHA levels on lung cancer risk. For the exposure data, we extracted genetic variants as instrumental variables (IVs) that are strongly associated with DHA from a large-scale genome-wide association study (GWAS). We obtained the corresponding effect estimates for IVs on the risk of lung cancer with 11,348 cases and 15,861 controls. Finally, we applied Mendelian randomization analysis to obtain preliminary MR results and performed sensitivity analyses to verify the robustness of our results. Results: According to the primary MR estimates and further sensitivity analyses, a higher serum DHA level was associated with a higher risk of lung cancer [OR = 1.159, 95% CI (1.04-1.30), P = 0.01]. For lung adenocarcinoma, the results also showed a close correlation between the DHA level and lung adenocarcinoma [OR = 1.277, 95% CI (1.09-1.50), P = 0.003], but it was not statistically significant for squamous cell carcinoma [OR = 1.071, 95% CI (0.89-1.29), P = 0.467]. Conclusions: Our study revealed that plasma DHA is positively associated with the risk of lung cancer overall, especially for lung adenocarcinoma. This study provides new information to develop dietary guidelines for primary lung cancer prevention. (c) 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/658526 |
| ISSN | 0261-5614 |
| DOI | 10.1016/j.clnu.2022.09.004 |
| Indexed | SCI(E) |
| Appears in Collections: | 中日友好医院 |
