| Title | Effect of lateral lymph nodes without malignant characteristics on the prognosis of patients with rectal cancer |
| Authors | Zhang, Chenghai Cui, Ming Xing, Jiadi Yang, Hong Yao, Zhendan Zhang, Nan Tan, Fei Liu, Maoxing Xu, Kai Su, Xiangqian |
| Affiliation | Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg 4, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fu Cheng Rd, Beijing 100142, Peoples R China |
| Keywords | PREOPERATIVE CHEMORADIOTHERAPY PELVIC RECURRENCE DISSECTION METASTASIS GUIDELINES CARCINOMA SURVIVAL COHORT COLON MRI |
| Issue Date | Nov-2022 |
| Publisher | FUTURE ONCOLOGY |
| Abstract | Plain language summary Lymph node metastasis in the pelvic sidewall of patients with rectal cancer is a serious disease that affects the patient's life expectancy. At present, the assessment of lateral lymph node (LLN) metastasis relies mainly on MRI. Currently, there is no consensus on whether small lymph nodes without malignant features detected by MRI affect patient prognosis. Therefore, the authors designed this study to compare the survival of patients with small LLNs detected by MRI with that of patients without LLNs. The authors found that the presence of LLNs, even without malignant features, may lead to worse local control and overall survival. Therefore, for patients with MRI-detected LLNs, LLN dissection should be conducted by experienced surgeons to improve patient prognosis. Background: Lateral lymph node (LLN) metastasis is a poor prognostic factor for rectal cancer patients. However, the effect of LLNs without malignant characteristics on the prognosis of rectal cancer patients has been uncertain. Methods: Consecutive patients who underwent laparoscopic-assisted low anterior resection were included. Patients with MRI-detected LLNs, but without malignant characteristics, were compared with patients with no MRI-detected LLNs. Results: The local recurrence rate was higher in the LLN-present group than in the LLN-absent group (9.8% vs 2.5%; p = 0.056). The overall survival of patients with no MRI-detected LLNs was significantly better than that of patients with MRI-detected LLNs (p = 0.021). Conclusion: The presence of LLNs, even without malignant features, may lead to worse local control and overall survival. |
| URI | http://hdl.handle.net/20.500.11897/657945 |
| ISSN | 1479-6694 |
| DOI | 10.2217/fon-2022-0476 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
