| Title | Cost-Effectiveness of COVID-19 Sequential Vaccination Strategies in Inactivated Vaccinated Individuals in China |
| Authors | Fu, Yaqun Zhao, Jingyu Wei, Xia Han, Peien Yang, Li Ren, Tao Zhan, Siyan Li, Liming |
| Affiliation | Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England Peking Univ, Ctr Publ Hlth & Epidem Preparedness & Response, Beijing 100191, Peoples R China |
| Keywords | HEALTH |
| Issue Date | Oct-2022 |
| Publisher | VACCINES |
| Abstract | To effectively prevent and control the COVID-19 pandemic, countries have adopted a booster vaccination strategy. This study aimed to estimate the cost-effectiveness of sequential booster COVID-19 vaccination compared to two-dose inactivated vaccination in China from a societal perspective. A Markov model was developed to estimate the cost-effectiveness of sequential vaccination, including two doses of an inactivated vaccine followed by a booster shot of an inactivated vaccine, adenovirus vectored vaccine, protein subunit vaccine, or mRNA vaccine. The incremental effects of a booster shot with an inactivated vaccine, protein subunit vaccine, adenovirus vectored vaccine, and mRNA vaccine were 0.0075, 0.0110, 0.0208, and 0.0249 QALYs and saved costs of US$163.96, US$261.73, US$583.21, and US$724.49, respectively. Under the Omicron virus pandemic, the sequential vaccination among adults and the elderly (aged 60-69, 70-79, over 80) was consistently cost-saving, and a booster shot of the mRNA vaccine was more cost-saving. The results indicate that the sequential vaccination strategy is cost-effective in addressing the COVID-19 pandemic, and improving vaccination coverage among the elderly is of great importance in avoiding severe cases and deaths. |
| URI | http://hdl.handle.net/20.500.11897/657627 |
| DOI | 10.3390/vaccines10101712 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
