| Title | Nano-Based Drug Delivery Systems for Periodontal Tissue Regeneration |
| Authors | Chen, Huanhuan Zhang, Yunfan Yu, Tingting Song, Guangying Xu, Tianmin Xin, Tianyi Lin, Yifan Han, Bing |
| Affiliation | Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China Beijing Key Lab Digital Stomatol, Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 100081, Peoples R China Univ Hong Kong, Fac Dent, Div Paediat Dent & Orthodont, Hong Kong, Peoples R China |
| Keywords | NF-KAPPA-B LIGAMENT STEM-CELLS GUIDED BONE OSTEOGENIC DIFFERENTIATION GENE DELIVERY PAMAM DENDRIMERS BUBBLE LIPOSOMES NITRIC-OXIDE TNF-ALPHA MEMBRANES |
| Issue Date | Oct-2022 |
| Publisher | PHARMACEUTICS |
| Abstract | Periodontitis is a dysbiotic biofilm-induced and host-mediated inflammatory disease of tooth supporting tissues that leads to progressive destruction of periodontal ligament and alveolar bone, thereby resulting in gingival recession, deep periodontal pockets, tooth mobility and exfoliation, and aesthetically and functionally compromised dentition. Due to the improved biopharmaceutical and pharmacokinetic properties and targeted and controlled drug release, nano-based drug delivery systems have emerged as a promising strategy for the treatment of periodontal defects, allowing for increased efficacy and safety in controlling local inflammation, establishing a regenerative microenvironment, and regaining bone and attachments. This review provides an overview of nano-based drug delivery systems and illustrates their practical applications, future prospects, and limitations in the field of periodontal tissue regeneration. |
| URI | http://hdl.handle.net/20.500.11897/657622 |
| DOI | 10.3390/pharmaceutics14102250 |
| Indexed | SCI(E) |
| Appears in Collections: | 口腔医院 |
