| Title | The effectiveness and safety of the rapid titration strategy of background controlled-release oxycodone hydrochloride for patients with moderate-to-severe cancer pain: A retrospective cohort study |
| Authors | Feng, Weineng Wang, Yufeng Ran, Fengming Mao, Yong Zhang, Helong Wang, Qifeng Lin, Wen Wang, Zhidong Hu, Jianli Liao, Wangjun Zhang, Tao Chu, Qian Xiong, Weijie Yi, Tienan Yi, Jiqun Ma, Shoucheng Sun, Yi Meng, Lingzhan Liu, Chunling Zhou, Silang Zheng, Dengyun Wang, Shubin Lin, Haifeng Fang, Wenzheng Li, Jun Wu, Minhui |
| Affiliation | First Peoples Hosp Foshan, Dept Head & Neck Thorac Med Oncol, Foshan, Peoples R China Yunnan Canc Hosp, Dept Cadre Med Sect, Kunming, Peoples R China Kunming Med Univ, Affiliated Hosp 3, Kunming, Peoples R China Yunnan Canc Ctr, Kunming, Peoples R China Hubei Canc Hosp, Dept Oncol, Wuhan, Peoples R China Yunnan Canc Hosp, Dept Pain Management, Kunming, Peoples R China AF Med Univ, Dept Oncol, Tangdu Hosp, Xian, Peoples R China UESTC, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Dept Thorac Radiotherapy,Canc Hosp,Sch Med, Guangzhou, Peoples R China Shantou Univ Med Coll, Dept Oncol, Canc Hosp, Shantou, Peoples R China Changsha Eighth Hosp, Changsha Hosp Tradit Chinese Med, Dept Oncol, Changsha, Peoples R China Huazhong Univ Sci & Technol, Canc Ctr, Tongji Med Coll, Xiehe Hosp, Wuhan, Peoples R China Southern Med Univ, Nanfang Hosp, Dept Oncol, Guangzhou, Peoples R China Chongqing Med Univ, Dept Oncol, Affiliated Hosp 1, Chongqing, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, Tongji Med Coll, Shanghai, Peoples R China Chengdu Fifth Peoples Hosp, Dept Oncol, Chengdu, Peoples R China Cent Hosp Xiangyang, Dept Oncol, Chengdu, Peoples R China Guangzhou Red Cross Hosp, Dept Oncol, Guangzhou, Peoples R China Lanzhou Univ, Dept Oncol, Hosp 1, Lanzhou, Peoples R China Hosp 452 PLA, Dept Hematol & Oncol, Chengdu, Peoples R China Chongqing Tradit Chinese Med Hosp, Dept Oncol, Chongqing, Peoples R China Chengdu Univ TCM, Clin Med Sch 4, Chongqing, Peoples R China Xinjiang Canc Hosp, Resp Dept, Urumqi, Peoples R China PLA Army 74 Grp Army Hosp, Dept Oncol, Guangzhou, Peoples R China Guangzhou Univ Chinese Med, Jinshazhou Hosp, Dept Oncol, Guangzhou, Peoples R China Peking Univ, Dept Oncol, Shenzhen Hosp, Shenzhen, Peoples R China Hainan Med Univ, Affiliated Hosp 2, Dept Oncol, Haikou, Hainan, Peoples R China Fuzhou PLA Gen Hosp, Dept Oncol, Fuzhou, Peoples R China Cent Hosp Wuhan, Dept Oncol, Wuhan, Peoples R China Xi An Jiao Tong Univ, Dept Integrated Chinese & Western Med, Shaanxi Canc Hosp, Coll Med, Xian, Peoples R China |
| Keywords | DOUBLE-BLIND IMMEDIATE-RELEASE MORPHINE EFFICACY TOLERABILITY MANAGEMENT OPIOIDS |
| Issue Date | 4-Oct-2022 |
| Publisher | FRONTIERS IN MEDICINE |
| Abstract | BackgroundOxycodone hydrochloride is a semisynthetic narcotic analgesic agent. This study aimed to explore optimal titration strategy of controlled-release (CR) oxycodone hydrochloride in patients with cancer pain. Methods258 patients, who used regular strong opioids (morphine and CR oxycodone hydrochloride) for cancer pain across 25 three grade class hospitals in China during January 15th 2017 to April 30th 2017, were retrospectively studied. The patients were divided into 4 groups according to treatment regimens titrated. The pain remission rate and numeric rating scale (NRS) of cancer pain was recorded at 0, 12, 24, 36, 48, 60, 72 h after opioid titration. The incidence of adverse events (AEs) with therapy were also observed. Results12 h after treatment, pain remission rate of Group B, C and D was significantly higher (P < 0.001) than Group A. For the complete remission rate, there were also significant differences among the four groups (P < 0.001). No significant difference was found among four groups for pain remission rate at 24, 72 h after treatment. Multiple comparison of NRS scores showed that the both Group B and C varied significantly with Group D (P = 0.028, P = 0.05, respectively), showing superior analgesic effect over Group D. AEs were significantly different among groups (P < 0.01), with the most frequent AEs in Group A, lowest in Group B. ConclusionThe rapid titration strategy of background CR oxycodone hydrochloride was effectiveness and safety in patients with moderate-to-severe cancer pain. |
| URI | http://hdl.handle.net/20.500.11897/657559 |
| DOI | 10.3389/fmed.2022.918468 |
| Indexed | SCI(E) |
| Appears in Collections: | 深圳医院 |
