| Title | Research to Clinics: Clinical Translation Considerations for Anodized Nano-Engineered Titanium Implants |
| Authors | Gulati, Karan Zhang, Yifan Di, Ping Liu, Yan Ivanovski, Saso |
| Affiliation | Univ Queensland, Sch Dent, Herston, Qld 4006, Australia Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Lab Biomimet Nanomat, Beijing, Peoples R China Peking Univ Sch, Beijing, Peoples R China |
| Keywords | LOCAL-DRUG DELIVERY FUNCTIONALIZED TIO2 NANOTUBES HUMAN GINGIVAL FIBROBLASTS MICRO-/NANO-TOPOGRAPHY DIOXIDE NANOPARTICLES DENTAL IMPLANT OSTEOGENIC ACTIVITY OXIDATIVE STRESS GENE-EXPRESSION DNA-DAMAGE |
| Issue Date | 10-Oct-2022 |
| Publisher | ACS BIOMATERIALS SCIENCE & ENGINEERING |
| Abstract | Titania nanotubes (TNTs) fabricated on titanium orthopedic and dental implants have shown significant potential in "proof of concept" in vitro, ex vivo, and short-term in vivo studies. However, most studies do not focus on a clear direction for future research towards clinical translation, and there exists a knowledge gap in identifying key research challenges that must be addressed to progress to the clinical setting. This review focuses on such challenges with respect to anodized titanium implants modified with TNTs, including optimized fabrication on clinically utilized microrough surfaces, clinically relevant bioactivity assessments, and controlled/ tailored local release of therapeutics. Further, long-term in vivo investigations in compromised animal models under loading conditions are needed. We also discuss and detail challenges and progress related to the mechanical stability of TNT-based implants, corrosion resistance/electrochemical stability, optimized cleaning/sterilization, packaging/aging, and nanotoxicity concerns. This extensive, clinical translation focused review of TNTs modified Ti implants aims to foster improved understanding of key research gaps and advances, informing future research in this domain. |
| URI | http://hdl.handle.net/20.500.11897/655866 |
| ISSN | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.1c00529 |
| Indexed | SCI(E) |
| Appears in Collections: | 口腔医院 |
