| Title | Impact of CYP2C19 gene polymorphisms on warfarin dose requirement: a systematic review and meta-analysis |
| Authors | Wang, Dongxu Yong, Ling Zhang, Qing Chen, Hao |
| Affiliation | CAMS&PUMC, Arrhythmia Ctr, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China CAMS&PUMC, Fuwai Hosp, Beijing 100037, Peoples R China Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100191, Peoples R China Beijing Hosp, Natl Ctr Gerontol, Dept Cardiovasc, Beijing 100730, Peoples R China |
| Keywords | ORAL ANTICOAGULANTS CLINICAL-OUTCOMES KOREAN PATIENTS GENOTYPE VKORC1 PERFORMANCE ALGORITHMS CLEARANCE |
| Issue Date | Oct-2022 |
| Publisher | PHARMACOGENOMICS |
| Abstract | Background: Various genetic factors influence warfarin maintenance dose. Methods: A literature search was performed on PubMed, Embase and the Cochrane Library, and a meta-analysis to analyze the impact of CYP2C19 polymorphisms on warfarin maintenance dose was conducted. Results: From nine studies encompassing 1393 patients, three CYP2C19 SNPs were identified: rs4244285, rs4986893 and rs3814637. Warfarin maintenance dose was significantly reduced by 10% in individuals with the rs4986893 A allele compared with the GG carriers and was 34%, 16% and 18% lower in patients with rs3814637 TT and CT genotypes and T allele, respectively, than that in CC carriers. No significant dose difference was observed among the rs4244285 genotypes. Conclusion: CYP2C19 rs4986893 and rs3814637 are associated with significantly reduced warfarin dose requirements. |
| URI | http://hdl.handle.net/20.500.11897/655760 |
| ISSN | 1462-2416 |
| DOI | 10.2217/pgs-2022-0106 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 |
