| Title | Dysregulation of glutamine/glutamate metabolism in COVID-19 patients: A metabolism study in African population and mini meta-analysis |
| Authors | Li, Xiao-Kun Tu, Bo Zhang, Xiao-Ai Xu, Wen Chen, Jia-Hao Zhao, Guang-Yu Xu, Biao Zheng, Jun-Jie Yan, Yan-Feng Hao, Peng-Fei Cole, Reginald Jalloh, Mohamed Boie Lu, Qing-Bin Li, Chang Sevalie, Stephen Liu, Wei Chen, Wei-Wei |
| Affiliation | Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Beijing 100039, Peoples R China Peking Univ, Dept Lab Sci & Technol, Sch Publ Hlth, Beijing, Peoples R China Republ Sierra Leone Armed Forces, Joint Med Unit, Freetown, Sierra Leone 34 Mil Hosp Wilberforce Freetown, Republ Sierra Leone Armed Forces, Joint Med Unit, Freetown, Sierra Leone |
| Keywords | GLUTAMINE INVOLVEMENT TISSUE |
| Issue Date | Oct-2022 |
| Publisher | JOURNAL OF MEDICAL VIROLOGY |
| Abstract | Coronavirus disease 2019 (COVID-19) remains a serious global threat. The metabolic analysis had been successfully applied in the efforts to uncover the pathological mechanisms and biomarkers of disease severity. Here we performed a quasi-targeted metabolomic analysis on 56 COVID-19 patients from Sierra Leone in western Africa, revealing the metabolomic profiles and the association with disease severity, which was confirmed by the targeted metabolomic analysis of 19 pairs of COVID-19 patients. A meta-analysis was performed on published metabolic data of COVID-19 to verify our findings. Of the 596 identified metabolites, 58 showed significant differences between severe and nonsevere groups. The pathway enrichment of these differential metabolites revealed glutamine and glutamate metabolism as the most significant metabolic pathway (Impact = 0.5; -log10P = 1.959). Further targeted metabolic analysis revealed six metabolites with significant intergroup differences, with glutamine/glutamate ratio significantly associated with severe disease, negatively correlated with 10 clinical parameters and positively correlated with SPO2 (r(s) = 0.442, p = 0.005). Mini meta-analysis indicated elevated glutamate was related to increased risk of COVID-19 infection (pooled odd ratio [OR] = 2.02; 95% confidence interval [CI]: 1.17-3.50) and severe COVID-19 (pooled OR = 2.28; 95% CI: 1.14-4.56). In contrast, elevated glutamine related to decreased risk of infection and severe COVID-19, the pooled OR were 0.30 (95% CI: 0.20-0A4), and 0.44 (95% CI: 0.19-0.98), respectively. Glutamine and glutamate metabolism are associated with COVID-19 severity in multiple populations, which might confer potential therapeutic target of COVID-19, especially for severe patients. |
| URI | http://hdl.handle.net/20.500.11897/655676 |
| ISSN | 0146-6615 |
| DOI | 10.1002/jmv.28150 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
