| Title | Deeper insight into the role of IL-17 in the relationship beween hypertension and intestinal physiology |
| Authors | Yang, Ze-Jun Wang, Tian-Tian Wang, Bo-Ya Gao, Han He, Cheng-Wei Shang, Hong-Wei Lu, Xin Wang, Ying Xu, Jing-Dong |
| Affiliation | Capital Med Univ, Sch Basic Med Sci, Clin Med Program 5 3, Beijing, Peoples R China Capital Med Univ, Beijing Zhen Hosp, Dept Cardiol, Beijing, Peoples R China Capital Med Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing, Peoples R China Peking Univ, Peoples Hosp, Program Clin Med 8, Beijing, Peoples R China Capital Med Univ, Sch Basic Med Sci, Morphol Expt Ctr, Beijing, Peoples R China Capital Med Univ, Beijing Tongren Hosp, Dept Dermatol, Beijing, Peoples R China |
| Keywords | MONOCYTE CHEMOATTRACTANT PROTEIN-1 II-INDUCED HYPERTENSION REGULATORY T-CELLS SEGMENTED FILAMENTOUS BACTERIA TGF-BETA T(H)17 CELLS TH17 CELLS IFN-GAMMA MACROPHAGE ACCUMULATION VASCULAR INFLAMMATION |
| Issue Date | 4-Oct-2022 |
| Publisher | JOURNAL OF INFLAMMATION-LONDON |
| Abstract | With the incidence of hypertension increasing worldwide, more and more the mechanisms of hypertension from the perspective of immunity have found. Intestinal microbiota as well as its metabolites relationship with hypertension has attracted great attention from both clinicians and investigators. However, the associations of hypertension with lesions of a large number of immune factors including IL-17, MCP-1, IL-6, TGF-beta, IL-10 and others have not been fully characterized. In this review, after introducing the immune factors as the most potent anti/pro-hypertension agents known, we provide detailed descriptions of the IL-17 involved in the pathology of hypertension, pointing out the underlying mechanisms and suggesting the clinical indications. |
| URI | http://hdl.handle.net/20.500.11897/655545 |
| ISSN | 1476-9255 |
| DOI | 10.1186/s12950-022-00311-0 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
