| Title | Associations between phthalate exposure and thyroid function in pregnant women during the first trimester |
| Authors | Yang, Zheng Zhang, Tao Shan, Danping Li, Ludi Wang, Shuo Li, Yingzi Du, Ruihu Wu, Shaowei Jin, Lei Lu, Xin Shang, Xuejun Wang, Qi |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Toxicol, 38 Xueyuan Rd, Beijing 100191, Peoples R China Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Occupat & Environm Hlth, Xian 710061, Peoples R China Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Inst Reproduct & Child Hlth, 38 Xueyuan Rd, Beijing 100191, Peoples R China Maternal & Child Hlth Care Hosp Haidian District, Beijing 100080, Peoples R China Nanjing Univ, Sch Med, Jinling Hosp, Dept Androl, Nanjing 210002, Peoples R China |
| Keywords | BISPHENOL-A IN-UTERO METABOLITES HORMONES AUTOIMMUNITY CHILDHOOD CONTAMINATION PLASTICIZERS PEROXIDASE CHILDREN |
| Issue Date | 1-Sep-2022 |
| Publisher | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY |
| Abstract | Phthalates are a class of environmental endocrine disruptors. Previous studies have demonstrated that phthalate exposure can affect thyroid function; however, limited studies have assessed the associations between phthalate exposure and thyroid function, especially thyroid autoimmunity in pregnant women during the first trimester. We recruited participants from a cohort of pregnant women in Beijing, China, and collected urine samples to measure ten phthalate metabolites, serum samples to measure free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb) during the first trimester. We included 325 pregnant women without thyroid diseases or dysfunction in this study. Associations between phthalate metabolites and thyroid function parameters were assessed with the Bayesian kernel machine regression (BKMR) model, multiple linear regression model, and restricted cubic spline. In the BKMR model analysis, compared to the 50th percentile, total urinary phthalate metabolites levels were negatively associated with serum TPOAb levels when phthalate metabolites were at or below the 40th percentile. Stratifying by body mass index, total urinary phthalate metabolites levels were negatively associated with serum TPOAb levels in normal weight women when phthalate metabolites were at or below the 45th percentile. However, total urinary phthalate metabolites levels were positively associated with serum TPOAb levels in underweight women when phthalate metabolites were at or below the 30th percentile. In restricted cubic spline analysis, L-shaped nonlinear associations of mono-(2-ethyl-5carboxypentyl) phthalate (MECPP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), di-(2-ethylhexyl) phthalate (sigma DEHP), and inverted S-shaped nonlinear association of mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) with TPOAb were observed. In conclusion, our findings suggest that phthalate exposure may affect thyroid autoimmunity in underweight pregnant women during early pregnancy, and the potential effects of phthalate exposure on thyroid autoimmunity may be nonlinear. |
| URI | http://hdl.handle.net/20.500.11897/655413 |
| ISSN | 0147-6513 |
| DOI | 10.1016/j.ecoenv.2022.113884 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
