| Title | Abnormal patterns of regional homogeneity and functional connectivity across the adolescent first-episode, adult first-episode and adult chronic schizophrenia |
| Authors | Yang, Yongfeng Sun, Yuqing Zhang, Yuliang Jin, Xueyan Li, Zheng Ding, Minli Shi, Han Liu, Qing Zhang, Luwen Su, Xi Shao, Minglong Song, Meng Zhang, Yan Li, Wenqiang Yue, Weihua Liu, Bing Lv, Luxian |
| Affiliation | Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China Int Joint Res Lab Psychiat & Neurosci Henan, Xinxiang 453002, Henan, Peoples R China Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China Chinese Inst Brain Res, Beijing 102206, Peoples R China |
| Keywords | MEDIAL FRONTAL GYRUS ONSET SCHIZOPHRENIA 1ST-DEGREE RELATIVES FMRI BIOMARKER |
| Issue Date | 2022 |
| Publisher | NEUROIMAGE-CLINICAL |
| Abstract | Functional deficits in schizophrenia (SZ) are observed prior to the onset of psychosis and differ at different stages of SZ. However, there is a paucity of studies focused on adolescent first-episode SZ (AOS), adult first-episode SZ (AFES), and adult chronic SZ (CHSZ). In this study, we investigated regional activity and corresponding func-tional connectivity alterations that have aimed to compare the three disease stages simultaneously. The subjects comprised 49 patients with AOS, 57 patients with AFES, 51 patients with CHSZ, 41 adolescent healthy controls, and 138 adult healthy controls. We compared regional homogeneity (ReHo) between patients at each disease stage with matched healthy controls. We focused on the shared brain regions that showed significant differences between SZ patients at the three different disease stages and healthy controls. Further analysis was conducted to explore whether the patterns of the whole brain functional connectivity alterations were similar. The putamen and medial frontal gyrus (MFG) showed consistently abnormal patterns in AOS, AFES, and CHSZ. Commonly decreased ReHo values in the MFG and increased ReHo values in the bilateral putamen were found in AOS, AFES, and CHSZ. Functional connectivity of MFG remained common abnormality in different SZ stage. In conclusion, ReHo abnormalities in the MFG and the putamen may be common abnormal patterns of brain function in the three different stages of SZ. The vmPFC-dlPFC FC abnormality common occurs in adolescence and adulthood.. This study may provide a more comprehensive understanding of the neurodevelopmental abnormality across the AOS, AFES, and CHSZ. |
| URI | http://hdl.handle.net/20.500.11897/655275 |
| ISSN | 2213-1582 |
| DOI | 10.1016/j.nicl.2022.103198 |
| Indexed | SCI(E) |
| Appears in Collections: | 第六医院 |
