| Title | Association of differential body water composition by sex, measured using BIA, with survival in a real-world lung cancer cohort |
| Authors | Zhao, Wanni Zhang, Qi Yang, Zhenpeng Rao, Benqiang Chen, Yongbing Yu, Kaiying Liang, Jianfeng Wang, Yixuan Zhang, Zhanzhi Wang, Xin Wang, Lin Zhang, Xiaowei Zhang, Bingdong Shi, Hanping |
| Affiliation | Capital Med Univ, Beijing Shijitan Hosp, Dept Gastrointestinal Surg Clin Nutr, Key Lab Canc FSMP State Market Regulat, Beijing, Peoples R China Peking Univ, Dept Neurosurg, Int Hosp, Beijing, Peoples R China |
| Keywords | MUSCULAR STRENGTH BIOELECTRICAL-IMPEDANCE PHASE-ANGLE MUSCLE MASS BIOIMPEDANCE RISK PERFORMANCE MANAGEMENT SARCOPENIA HYDRATION |
| Issue Date | Nov-2022 |
| Publisher | NUTRITION |
| Abstract | Objective: The aim of this study was to evaluate the association of differential body water composition with survival in patients with lung cancer.Methods: This retrospective cohort study included 1314 patients diagnosed with lung cancer in 80 Chinese institutions from May 2013 to August 2020. We calculated hazard ratios (HRs) to evaluate the associations of all-cause mortality with extracellular water (ECW) and intracellular water (ICW). Cox proportional risk regression models were adjusted for sociodemographic characteristics, tumor characteristics, treatment, body mass index (BMI), and body composition measures. We also evaluated cross-classification of the dichot-omy of ECW and ICW with outcomes. The association among ECW, ICW, and survival was evaluated via Cox regression and the restricted cubic-spline model using a two-sided P value.Results: The study included 819 (62%) men and 495 (28%) women. The HR of lung cancer mortality signifi-cantly decreased as ECW increased (HR, 0.96; 95% confidence interval [CI], 0.93-1.00) and ICW (HR, 0.97; 95% CI, 0.95-1.00) with cutoff values of 10.5 and 16.3 L, respectively. When patients were cross-classified into categories of sex, age, BMI, visceral fat index, pathology, tumor stage, tumor burden, total bilirubin, and neutrophil count, ICW and ECW were protective factors. Only sex interacted significantly with ICW or ECW. High ICW and ECW had significant protective effects, and women had a greater risk for death than men in the case of either poor ICW or poor ECW. Sensitivity analysis showed the protective effect of the higher dichotomy of ICW (HR, 0.52; 95% CI, 0.35-0.78) and ECW (HR, 0.45; 95% CI, 0.31-0.66) on female lung cancer patients by removing patients who died within 12 mo of diagnosis.Conclusion: Greater ICW and ECW, especially ICW, were independent predictors for better survival in patients with lung cancer. Female patients were more vulnerable to dehydration than male patients.(c) 2022 Elsevier Inc. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/655094 |
| ISSN | 0899-9007 |
| DOI | 10.1016/j.nut.2022.111804 |
| Indexed | SCI(E) |
| Appears in Collections: | 国际医院 |
