| Title | Associations of forest negative air ions exposure with cardiac autonomic nervous function and the related metabolic linkages: A repeated-measure panel study |
| Authors | Liu, Shan Li, Chen Chu, Mengtian Zhang, Wenlou Wang, Wanzhou Wang, Yazheng Guo, Xinbiao Deng, Furong |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China |
| Keywords | PARTICULATE MATTER SYSTEM RISK WALKING HEALTH TRIAL |
| Issue Date | 1-Dec-2022 |
| Publisher | SCIENCE OF THE TOTAL ENVIRONMENT |
| Abstract | Forest environment has many health benefits, and negative air ions (NAI) is one of the major forest environmental fac-tors. Many studies have explored the effect of forest environment on cardiac autonomic nervous function, while forest NAI in the among function and the underlying mechanism still remain unclear. To explore the associations and molec-ular linkages between short-term exposure to forest NAI and heart rate variability (HRV), a repeated-measure panel study was conducted among 31 healthy adults. Participants were randomly selected to stay in a forest park for 3 days and 2 nights. Individual exposures including NAI were monitored simultaneously and HRV indices were mea-sured repeatedly at the follow-up period. Urine samples were collected for non-targeted metabolomics analysis. Mixed-effect models were adopted to evaluate associations among NAI, HRV indices and metabolites. The median of NAI concentration was 68.11 (138.20) cm-3 during the study period. Short-term exposure to forest NAI was asso-ciated with the ameliorative HRV indices, especially the excitatory parasympathetic nerve. For instance, per inter -quartile range increase of 5-min moving average of NAI was associated with 9.99 % (95%CI: 8.95 %, 11.03 %) increase of power in high frequency. Eight metabolites were associated with NAI exposure. The down-regulated tyro-sine metabolism was firstly observed, followed by other amino acid metabolic alterations. The NAI-related metabolic changes reflect the reduction of inflammation and oxidative stress. HRV indices were associated with 25 metabolites, mainly including arginine, proline and histidine metabolism. Short-term exposure to forest NAI is beneficial to HRV, especially to the parasympathetic nerve activity, by successively disturbing different metabolic pathways which mainly reflect the increased anti-inflammation and the reduced inflammation. The results will provide epidemiologi-cal evidences for developing forest therapy and improving cardiac autonomic nervous function. |
| URI | http://hdl.handle.net/20.500.11897/655003 |
| ISSN | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2022.158019 |
| Indexed | EI SCI(E) |
| Appears in Collections: | 公共卫生学院 |
