| Title | Preoperative systemic chemotherapy does not benefit for appendiceal pseudomyxoma peritonei |
| Authors | Ma, Ruiqing Lu, Dongmei Xue, Shilin Fan, Xiwen Zhai, Xichao Wang, Chong Xu, Hongbin Pang, Shaojun |
| Affiliation | Aerosp Ctr Hosp, Dept Myxoma, 15 Yuquan Rd, Beijing, Peoples R China Aerosp Ctr Hosp, Dept Hlth Management, Beijing, Peoples R China Peking Univ, Aerosp Sch Clin Med, Beijing, Peoples R China |
| Keywords | HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY CYTOREDUCTIVE SURGERY CANCER ORIGIN CLASSIFICATION PROGNOSIS CONSENSUS OUTCOMES |
| Issue Date | Sep-2022 |
| Publisher | ANZ JOURNAL OF SURGERY |
| Abstract | Background Pseudomyxoma peritonei (PMP) is a clinically malignant tumour syndrome mainly derived from mucin-producing appendiceal tumours. This study aimed to explore the effect of preoperative systemic chemotherapy (PSC) before cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) on the safety and postoperative survival in patients with appendiceal PMP. Methods We performed a retrospective analysis including consecutive patients with PMP undergoing primary surgery between January, 2008 and December, 2019 in Aerospace Center Hospital. The clinical data and postoperative survival were compared between PSC group and non-PSC group. Results Seven hundred and fifty patients were included in the study. Significant differences were found between PSC group and non-PSC group on clinicopathological data and perioperative outcomes and the independent risk factor of serious complications was blood loss >1000 mL (P = 0.026). Shorter median overall survival (OS) was found (42 months, 95% CI 31.9-52.1) in PSC group than that (67 months 95% CI 44.5-89.5) in non-PSC group. In the stratified study with PCI < 20, CC 0/1 and low-grade pathological subtype, the OS from non-PSC group was significantly better than that in PSC group (log rank P-values are <0.001, 0.006 and <0.001, respectively). Multivariate survival analysis showed that CC 0/1, HIPEC, PCI < 20 and low-grade pathological subtype were the independent prognostic factors for better OS. Conclusions PSC does not increase the risk of major perioperative complications in patients with appendiceal PMP, but it also does not bring postoperative survival benefits to patients either. |
| URI | http://hdl.handle.net/20.500.11897/654841 |
| ISSN | 1445-1433 |
| DOI | 10.1111/ans.18041 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京航天中心医院 |
