| Title | Brain regions involved in fractional amplitude of low-frequency fluctuation in cluster headache patients: a resting-state functional MRI study |
| Authors | Chen, Yun Xing, Xinbo Dai, Wei Tian, Lixia Dong, Zhao Yu, Shengyuan |
| Affiliation | Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Int Headache Ctr, Beijing, Peoples R China Chinese PLA Med Sch, Beijing 100853, Peoples R China Peking Univ, Dept Neurol, Shougang Hosp, Beijing 100144, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Med Ctr 4, Beijing 100048, Peoples R China Beijing Jiaotong Univ, Sch Comp & Informat Technol, Beijing 100044, Peoples R China |
| Keywords | TRANSCRANIAL MAGNETIC STIMULATION MATTER VOLUME NETWORK DYSFUNCTION PREVALENCE PLASTICITY CORTEX FALFF FMRI ALFF |
| Issue Date | 7-Sep-2022 |
| Publisher | BMC NEUROLOGY |
| Abstract | Background We used resting-state functional magnetic resonance imaging (RS-fMRI) to assess the possible pathogenic role of fALFF in CH. A limited number of studies have reported on fractional amplitude of low-frequency fluctuation (fALFF) in cluster headache (CH). Methods RS-fMRI scans of 23 patients with CH were obtained (11with left-sided headache and 12 with right-sided headache), along with scans of 23 age- and sex-matched normal controls. The RS-fMRI data were analyzed to explore abnormal brain activity in the left CH and right CH patients during the non-painful state in one cluster period. fALFF was compared between patients and controls, and correlation analysis between the regional mean fALFF values and clinical characteristics was performed. Results A decrease in fALFF was detected in the left cerebellum, left lentiform nucleus, left frontal lobe, left anterior cingulate, and right postcentral gyrus in the left CH group compared to the controls, while a decrease of fALFF was detected in the right cerebellum, right cingulate gyrus, right superior parietal lobule, right inferior parietal lobule, right postcentral gyrus, and left precuneus in the right CH group. No patient had a region with increased fALFF. A moderate correlation was observed between some regional mean fALFF values and the clinical characteristics. Conclusions We deduced that dysfunction in multiple brain areas is involved in the non-painful state of CH during a cluster period. |
| URI | http://hdl.handle.net/20.500.11897/654304 |
| DOI | 10.1186/s12883-022-02863-3 |
| Indexed | SCI(E) |
| Appears in Collections: | 首钢医院 |
