| Title | Association of anxiety with cardiovascular disease in a Chinese cohort of 0.5 million adults |
| Authors | Wu, Man Zhu, Yunqing Lv, Jun Guo, Yu Yang, Ling Chen, Yiping Tang, Wei Xiang, Shengping Sun, Xiaohui Chen, Junshi Chen, Zhengming Yu, Canqing Li, Liming |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China Peking Univ, Ctr Publ Hlth & Epidem Preparedness & Response, Beijing 100191, Peoples R China Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China Univ Oxford, Med Res Council, Populat Hlth Res Unit, Oxford OX37LF, Oxon, England Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford OX37LF, Oxon, England Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford OX37LF, Oxon, England Pengzhou Tradit Chinese Med Hosp, Emergency Dept, Pengzhou 611930, Sichuan, Peoples R China Pengzhou Tongyi Hosp, Pengzhou 611930, Sichuan, Peoples R China Qingdao CDC, NCDs Prevent & Control Dept, Qingdao 266033, Shandong, Peoples R China Peking Univ, Dept Epidemiol & Biostat, Hlth Sci Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China |
| Keywords | CORONARY-HEART-DISEASE PANIC DISORDER RISK STROKE DEPRESSION KADOORIE EVENTS |
| Issue Date | 15-Oct-2022 |
| Publisher | JOURNAL OF AFFECTIVE DISORDERS |
| Abstract | Background: Anxiety might be a potentially modifiable risk factor of cardiovascular diseases (CVDs). Evidence relating anxiety symptoms and generalized anxiety disorder (GAD) to CVDs from prospective cohort study was still lacking in China.Methods: Participants aged 30 to 79 years old from 10 areas across China were recruited during 2004-2008 and were followed up until 2017. 487,209 participants without CVDs at baseline remained for analyses. Anxiety symptoms (panic attacks and continuous anxiety) during the past 12 months were identified in a face-to-face interview. Participants with continuous anxiety were further assessed for GAD using Composite International Diagnostic Interview-Short Form. The primary outcomes were incident CVD, ischaemic heart disease (IHD), haemorrhagic stroke (HS), and ischaemic stroke (IS).Results: During 4.7 million person-years of follow-up, we documented 140,365 incident cases of CVD. For panic attacks, the multivariable-adjusted HRs (95 % CI) were 1.08 (1.04-1.13), 1.10 (1.02-1.19), 1.20 (1.05-1.38) and 1.20 (1.11-1.30) for CVD, IHD, HS and IS, respectively. Continuous anxiety was positively associated with incident CVD and IHD, and the corresponding HRs were 1.12 (1.04-1.20) and 1.21 (1.07-1.37).Limitations: Anxiety symptoms were examined according to self-reported questionnaires, which could constitute key study limitations.Conclusions: Among the Chinese adults, those with anxiety symptoms or GAD might be important at-risk pop-ulation of CVD. |
| URI | http://hdl.handle.net/20.500.11897/654116 |
| ISSN | 0165-0327 |
| DOI | 10.1016/j.jad.2022.08.008 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 公共卫生学院 |
