| Title | Long-Term Exposure to Ozone Increases Neurological Disability after Stroke: Findings from a Nationwide Longitudinal Study in China |
| Authors | Li, Jiajianghui Lu, Hong Cao, Man Tong, Mingkun Wang, Ruohan Yang, Xinyue Liu, Hengyi Xiao, Qingyang Chao, Baohua Liu, Yuanli Xue, Tao Guan, Tianjia |
| Affiliation | Peking Univ, Sch Publ Hlth, Inst Reprod & Child Hlth, Natl Hlth Commiss Key Lab Reprod Hlth, Beijing 100191, Peoples R China Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Sch Hlth Policy & Management, Beijing 100730, Peoples R China Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China Natl Hlth Commiss Peoples Republ China, Gen Off Stroke Prevent Project Comm, Beijing 100053, Peoples R China |
| Keywords | AIR-POLLUTION GLOBAL BURDEN DISEASE ASSOCIATION PREVENTION PREVALENCE MECHANISMS MORTALITY RISK |
| Issue Date | Aug-2022 |
| Publisher | BIOLOGY-BASEL |
| Abstract | Exposure to ozone (O-3) is associated with stroke incidence and mortality. However, whether long-term exposure to O-3 is associated with post-stroke neurological disability remains unknown. This study investigated the relationship based on the longitudinal analysis of China National Stroke Screening Survey (CNSSS), which included 65,778 records of stroke patients. All of the analyzed patients were followed-up at least twice. Stroke disability was assessed using the modified Rankin scale (mRS). Long-term exposure was assessed by the peak-season or annual mean of maximum 8-h O-3 concentrations for 365 days before the mRS measurement. We used fixed-effect models to evaluate the associations between O-3 and mRS score, with adjustment for multiple confounders, and found a 10 mu g/m(3) increase in peak-season O-3 concentration was associated with a 0.0186 (95% confidence interval [CI] 0.0115-0.0256) increment in the mRS score. The association was robust in various subpopulations. For secondary outcomes, for each 10 mu g/m(3) increment in peak-season O-3, the odds ratio of an increased mRS score (vs. unchanged or decreased mRS score) increased by 23% (95% CI 9-37%). A nonlinear analysis showed a sublinear association between O-3 exposure and risk for post-stroke disability. A saturation effect was observed at an O-3 concentration of more than similar to 120 mu g/m(3). Our study adds to evidence that long-term exposure to O-3 increases the risk of neurological disability after stroke. |
| URI | http://hdl.handle.net/20.500.11897/652508 |
| DOI | 10.3390/biology11081216 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 环境科学与工程学院 |
