| Title | Prognosis and Risk Factors of Recurrence in HBV-Related Small Hepatocellular Carcinoma After Stereotactic Body Radiation Therapy |
| Authors | Han, Yifan Liu, Jianxiang Pan, Jiali Chen, Hongyu Tan, Ning Kang, Qian Yang, Yuqing Xu, Xiaoyuan Li, Wengang |
| Affiliation | Peking Univ, Peking Univ Hosp 1, Dept Infect Dis, Beijing, Peoples R China Peking Univ, Peking Univ Hosp 1, Dept Gastroenterol, Beijing, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Radiat Oncol Dept, Beijing, Peoples R China |
| Keywords | PLATELET RATIO INDEX ASPARTATE-AMINOTRANSFERASE SURVIVAL ANALYSIS LIVER-CIRRHOSIS RADIOTHERAPY RESECTION ABLATION CANCERS |
| Issue Date | 25-Jul-2022 |
| Publisher | FRONTIERS IN ONCOLOGY |
| Abstract | ObjectiveThe role of stereotactic body radiation therapy (SBRT) for treating small hepatocellular carcinoma (sHCC) has gained increasing recognition. However, the prognosis and risk factors for recurrence in patients with sHCC remain unclear. This study investigated the risk factors for the recurrence of hepatitis B virus (HBV)-related sHCC after SBRT. MethodsA total of 240 HBV-related sHCC patients treated with SBRT between March 2011 and March 2020 were retrospectively analyzed. The cumulative probability of recurrence was calculated according to the Kaplan-Meier method. Univariate and multivariate analyses were performed with Cox proportional hazard models. ResultsRecurrent hepatocellular carcinoma developed in 134 (55.8%) patients at a median time of 27 months after SBRT. The one- and two-year rates of recurrence were 20.9 and 45.0%, respectively. The median follow-up time was 30 months. The Cox multivariate analysis indicated that age (P = 0.029, HR [1.019, 1.002-1.037]), tumor size (P = 0.012, HR [1.227, 1.045-1.440]), and aspartate aminotransferase-to-platelet ratio index (APRI) (P = 0.005, HR [1.911, 1.221-2.989]) were independent risk factors for recurrence. ConclusionPatients receiving SBRT for HBV-related sHCC may be at greater risk of recurrence if they have a high APRI score combined with advanced age and large tumor size. |
| URI | http://hdl.handle.net/20.500.11897/650322 |
| ISSN | 2234-943X |
| DOI | 10.3389/fonc.2022.903355 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 校医院 |
