| Title | Isoschaftoside Reverses Nonalcoholic Fatty Liver Disease via Activating Autophagy In Vivo and In Vitro |
| Authors | Su, Yanze Kang, Yixing Yi, Jing Lin, Qirui Zhang, Chaochuang Lin, Zewei Yan, Zilong Qu, Jianhua Liu, Jikui |
| Affiliation | Weifang Med Univ, Dept Clin Med, Weifang 261031, Peoples R China Peking Univ, Dept Hepatobiliary & Pancreat Surg, Shenzhen Hosp, Shenzhen 518036, Peoples R China |
| Keywords | FLAVONOID C-GLYCOSIDES ABRUS-MOLLIS APOPTOSIS HEALTH |
| Issue Date | 27-Jun-2022 |
| Publisher | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE |
| Abstract | Nonalcoholic fatty liver disease (NAFLD) is the most common metabolic liver disease globally, and the incidence of NAFLD has been increasing rapidly year by year. Currently, there is no effective pharmacotherapy for NAFLD. Therefore, studies are urgently needed to explore therapeutic drugs for NAFLD. In this study, we show that isoschaftoside (ISO) dramatically reduces lipid deposition in cells. Meanwhile, ISO treatment reverses the NAFLD and reduces hepatic steatosis in mice. Importantly, we reveal that ISO suppresses the expression of light-chain 3-II (LC3-II) and SQSTM1/p62 in palmitic acid (PA) induced autophagy inhibition in the cell model and the NAFLD mouse model, which suggests that ISO might reverse NAFLD through regulating autophagy flux. We propose that ISO might alleviate hepatic steatosis in NAFLD via regulating autophagy machinery. Consequently, our study suggests that ISO might be of potential clinical value in the field of NAFLD therapy. ISO might have the potential for future therapeutic application. |
| URI | http://hdl.handle.net/20.500.11897/649717 |
| ISSN | 1741-427X |
| DOI | 10.1155/2022/2122563 |
| Indexed | SCI(E) |
| Appears in Collections: | 深圳医院 |
