| Title | Associations of essential element serum concentrations with autism spectrum disorder |
| Authors | Wu, Jing Wang, Dongfang Yan, Lailai Jia, Meixiang Zhang, Jishui Han, Songping Han, Jisheng Wang, Jingyu Chen, Xi Zhang, Rong |
| Affiliation | Peking Univ, Med & Hlth Anal Ctr, Beijing 100191, Peoples R China Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing 100191, Peoples R China Capital Med Univ, Dept Neurol, Beijing Childrens Hosp, Beijing 100045, Peoples R China Capital Med Univ, Ctr Rehabil, Beijing Childrens Hosp, Beijing 100045, Peoples R China Natl Ctr Childrens Hlth, Beijing 100045, Peoples R China Wuxi Shenpingxintai Med Technol Co Ltd, Wuxi 214000, Jiangsu, Peoples R China Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China Peking Univ, Natl Hlth & Family Planning Commiss, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Hlth Sci Ctr, Beijing 100191, Peoples R China Chinese Ctr Dis Control & Prevent, Natl Inst Environm Hlth, Beijing 100050, Peoples R China Univ Hlth Sci Ctr, Autism Res Ctr Peking, Beijing 100191, Peoples R China |
| Keywords | IODINE DEFICIENCY OXIDATIVE STRESS ZINC SUPPLEMENTATION TRACE-ELEMENTS CHILDREN COPPER SELENIUM POTASSIUM LITHIUM METALS |
| Issue Date | Jul-2022 |
| Publisher | ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH |
| Abstract | This case-control study explored the associations between autism spectrum disorder (ASD) and the serum concentration of nine chemical elements in children. The study recruited 92 Chinese children with ASD and 103 typically developing individuals. Serum concentrations of nine chemical elements (calcium, iodine, iron, lithium, magnesium, potassium, selenium, strontium, and zinc) were determined by inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma atomic emission spectrometry (ICP-AES). An unconditional logistic regression model was used to analyze the associations between the serum concentrations of the elements and the risk of ASD. After adjusting for confounders, the multivariate analysis results showed that zinc <= 837.70 ng/mL, potassium > 170.06 mu g/mL, and strontium <= 52.46 ng/mL were associated with an increased risk of ASD, while selenium > 159.80 ng/mL was associated with a decreased risk of ASD. Furthermore, the degree of lithium and zinc deficiency was associated with ASD severity. The results indicated that metallomic profiles of some specific elements might play important roles in the development of ASD, a finding of scientific significance for understanding the etiology, and providing dietary guidance for certain ASD types. |
| URI | http://hdl.handle.net/20.500.11897/649241 |
| ISSN | 0944-1344 |
| DOI | 10.1007/s11356-022-21978-1 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 第六医院 基础医学院 |
