| Title | Biomimetically constructing a hypoxia-activated programmable phototheranostics at the molecular level |
| Authors | Zhang, Hang Wu, Jia-Hui Xue, Hao-Zong Zhang, Ruijing Yang, Zi-Shu Gao, Song Zhang, Jun-Long |
| Affiliation | Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China South China Univ Technol, Sch Chem & Chem Engn, Spin X Inst, Guangdong Hong Kong Macao Joint Lab Optoelect & M, Guangzhou 510641, Guangdong, Peoples R China Chem & Chem Engn Guangdong Lab, Shantou 515031, Peoples R China |
| Keywords | PHOTODYNAMIC THERAPY CANCER ACID PHOTOSENSITIZERS NANOPARTICLES ANGIOGENESIS COMBINATION OXYGEN |
| Issue Date | Jul-2022 |
| Publisher | CHEMICAL SCIENCE |
| Abstract | The hypoxic microenvironment is considered the preponderant initiator to trigger a cascade of progression and metastasis of tumors, also being the major obstacle for oxygen consumption therapeutics, including photodynamic therapy (PDT). In this work, we report a programmable strategy at the molecular level to modulate the reciprocal interplay between tumor hypoxia, angiogenesis, and PDT outcomes by reinforcing synergistic action between a H2O2 scavenger, O-2 generator and photosensitizer. The modular combination of a catalase biomimetic (tri-manganese cryptand, 1) and a photosensitizer (Ce6) allowed the rational design of a cascade reaction beginning with dismutation of H2O2 to O-2 under hypoxic conditions to enhance photosensitization and finally photooxidation. Concurrently, this led to the decreased expression of the vascular endothelial growth factor (VEGF) and effectively reduced unwanted growth of blood vessels observed in the chick chorioallantois membrane (CAM). Notably, the proof-of-principle experiments using the tumor-bearing models proved successful in enhancing PDT efficacy, prolonging their life cycles, and improving immunity, which could be monitored by magnetic resonance imaging (MRI). |
| URI | http://hdl.handle.net/20.500.11897/649201 |
| ISSN | 2041-6520 |
| DOI | 10.1039/d2sc02554j |
| Indexed | SCI(E) |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ |
