| Title | Thrombocytopenia and increased risk of adverse outcome in COVID-19 patients |
| Authors | Yuan, Yang Wang, Gang Chen, Xi Ye, Xiao-Lei Li, Xiao-Kun Li, Rui Jiang, Wan-Li Zeng, Hao-Long Du, Juan Zhang, Xiao-Ai Li, Hao Fang, Li-Qun Lu, Qing-Bin Liu, Wei |
| Affiliation | Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China Huazhong Univ Sci & Technol, Wuhan Hosp 1, Tongji Med Coll, Dept Thorac & Vasc Surg, Wuhan, Peoples R China Wuhan Univ, Sch Hlth Sci, Dept Healthcare, Wuhan, Hubei, Peoples R China Wuhan Univ, Global Hlth Inst, Wuhan, Hubei, Peoples R China Wuhan Univ, Dept Thorac Surg, Renmin Hosp, Wuhan, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Lab Med, Wuhan, Peoples R China Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, Beijing, Peoples R China |
| Keywords | INFECTIONS PLATELETS |
| Issue Date | 30-Jun-2022 |
| Publisher | PEERJ |
| Abstract | Background. Thrombocytopenia was common in the coronavirus disease 2019 (COVID-19) patients during the infection, while the role of thrombocytopenia in COVID-19 pathogenesis and its relationship with systemic host response remained obscure. The study aimed to systematically evaluate the relationship between thrombo-cytopenia in COVID-19 patients and clinical, haematological and biochemical markers of the disease as well as adverse outcomes. Methods. To assess the relationship between abnormal platelet levels and disease progression, a multi-center retrospective cohort study was conducted. COVID-19 patients with thrombocytopenia and a sub-cohort of matched patients without thrombocytopenia were compared for their clinical manifestations, haematological disorders, biochemical parameters, inflammatory markers and clinical outcome. Results. Thrombocytopenia was present in 127 of 2,209 analyzed patients on admission. Compared with the control group, thrombocytopenia patients developed significantly higher frequency of respiratory failure (41.9% vs. 22.6%, P = 0.020), intensive care unit entrance (25.6% vs. 11.5%, P = 0.012), disseminated intravascular coagulation (45.2% vs. 10.6%, P < 0.001), more altered platelet morphology indexes and coagulation perturbation, higher levels of inflammatory markers. In addition, a significantly increased all-cause mortality (hazard ratio 3.08, 95% confidence interval 2.26-4.18, P < 0.001) was also observed in the patients with thrombocytopenia. Late development of thrombocytopenia beyond 14 days post-symptom was observed in 61 patients, from whom a comparable mortality rate yet longer duration to death was observed compared to those with early thrombocytopenia. Conclusions. Our finding from this study adds to previous evidence that thrombocytopenia is associated with adverse outcome of the disease and recommend that platelet count and indices be included alongside other haematological, biochemical and inflammatory markers in COVID-19 patients' assessment during the hospital stay. |
| URI | http://hdl.handle.net/20.500.11897/649179 |
| ISSN | 2167-8359 |
| DOI | 10.7717/peerj.13608 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
