| Title | Neurological manifestations in COVID-19 patients and their application in predicting fatal disease: A retrospective cohort study |
| Authors | Zhao, Tian-Shuo Zeng, Hao-Long Zhang, Xin Chen, Xi Jiang, Wan-Li Du, Juan Liu, Han-Yu Zhao, Jing Yuan, Yang Peng, Xue-Fang Li, Jia-Chen Yang, Tong Liu, Bao-Cheng Li, Hui-Jun Zhang, Xiao-Ai Fang, Li-Qun Lu, Qing-Bin Cui, Fuqiang Liu, Wei |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, Beijing 100191, Peoples R China Peking Univ, Vaccine Res Ctr, Sch Publ Hlth, Beijing 100191, Peoples R China Huazhong Univ ofScience & Technol, Tongji Hosp, Tongji Med Coll, Dept Lab Med, Wuhan 430030, Peoples R China Huangmei Peoples Hosp, Huanggang 436500, Peoples R China Huazhong Univ Sci & Technol, Wuhan No Hosp 1, Tongji Med Coll, Dept Thorac & Vasc Surg, Wuhan 430022, Peoples R China Renmin Hosp Wuhan Univ, Dept Thorac Surg, Wuhan 430060, Peoples R China Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, 38 Xue-Yuan Rd, Beijing 100191, Peoples R China Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, 20 Dong-Da St, Beijing 100071, Peoples R China |
| Keywords | CORONAVIRUS |
| Issue Date | Jun-2022 |
| Publisher | JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION |
| Abstract | Background: To explore the development of central nervous system (CNS) symptoms and clinical application in predicting the clinical outcomes of SARS-COV-2 patients.Methods: A retrospective cohort study was performed on the hospitalized patients with SARSCOV-2 recruited from four hospitals in Hubei Province, China from 18 January to 10 March 2020. The patients with CNS symptoms were determined. Data regarding clinical symptoms and laboratory tests were collected from medical records. Results: Of 1268 patients studied, 162 (12.8%) had CNS symptoms, manifested as unconscious-ness (71, 5.6%), coma (69, 5.4%), dysphoria (50, 3.9%), somnolence (34, 2.7%) and convulsion (3, 0.2%), which were observed at median of 14 (interquartile range 9-18) days after symptom onset and significantly associated with older age (OR = 5.71, 95% confidence interval [CI] 2.78-11.73), male (OR = 1.73, 95% CI 1.22-2.47) and preexisting hypertension (OR = 1.78, 95% CI 1.23-2.57). The presence of CNS symptoms could be predicted by abnormal laboratory tests across various clinical stages, including by lymphocyte counts of <0.93 x 109/L, LDH>435 U/L and IL-6>28.83 pg/L at 0-10 days post disease; by lymphocyte count<0.86 x 109/L, IL -2R > 949 U/L, LDH>382 U/L and WBC>8.06 x 109/L at 11-20 days post disease. More patients with CNS symptoms developed fatal outcome compared with patients without CNS symptoms (HR = 33.96, 95% CI 20.87-55.16).Conclusion: Neurological symptoms of COVID-19 were related to increased odds of developing poor prognosis and even fatal infection.Copyright (c) 2021, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| URI | http://hdl.handle.net/20.500.11897/648241 |
| ISSN | 1684-1182 |
| DOI | 10.1016/j.jmii.2021.07.010 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
