| Title | Efficacy of the Oral Administration of Maltodextrin Fructose Before Major Abdominal Surgery: A Prospective, Multicenter Clinical Study |
| Authors | Qin, Huanlong Ji, Jiafu Miao, Yi Liu, Tong Zhao, Dongbing Jia, Zhenyi Jiang, Jun Liu, Jiang Li, Qiang Ji, Xi Fu, Weihua Lou, Donghua Xia, Wenyu Li, Ning |
| Affiliation | Shanghai Tenth Peoples Hosp, Dept Gen Surg, Shanghai, Peoples R China Peking Univ, Dept Gastrointestinal Surg, Canc Hosp, Beijing, Peoples R China Nanjing Med Univ, Jiangsu Prov Hosp, Affiliated Hosp 1, Pancreas Ctr, Nanjing, Peoples R China Tianjin Med Univ, Dept Gen Surg, Gen Hosp, Tianjin, Peoples R China Natl Canc Ctr, Dept Pancreat & Gastr Surg Oncol, Natl Clin Res Ctr Canc, Canc Hosp, Beijing, Peoples R China Shanghai Sixth Peoples Hosp, Dept Gen Surg, Shanghai, Peoples R China Nanjing Univ, Jinling Hosp, Dept Gen Surg, Med Sch, Nanjing, Peoples R China Shanghai Tenth Peoples Hosp, Dept Anesthesiol, Shanghai, Peoples R China Nanjing Med Univ, Sch Publ Hlth, Nanjing, Jiangsu, Peoples R China Shanghai Tenth Peoples Hosp, Dept Colorectal Dis, Shanghai, Peoples R China Jiangsu Chia Tai Fenghai Pharmaceut Co Ltd, Nanjing, Jiangsu, Peoples R China |
| Keywords | CARBOHYDRATE TREATMENT COLORECTAL SURGERY METAANALYSIS RECOVERY TRIAL |
| Issue Date | Jun-2022 |
| Publisher | WORLD JOURNAL OF SURGERY |
| Abstract | Background To study the efficacy of the oral administration of maltodextrin and fructose before major abdominal surgery (MAS). Methods This prospective, multicenter, parallel-controlled, double-blind study included patients aged 45-70 years who underwent elective gastrectomy, colorectal resection, or duodenopancreatectomy. The intervention group (IG) was given 800 mL and 400 mL of a maltodextrin and fructose beverage at 10 h and 2 h before MAS, respectively, and the control group (CG) received water under the same experimental conditions. The primary endpoint was insulin resistance index (IRI), and the secondary endpoints were fasting blood glucose, fasting insulin, insulin secretion index, insulin sensitivity index, intraoperative blood glucose, subjective comfort score, and clinical outcome indicators. Results A total of 240 cases were screened, of which 231 cases were randomly divided into two groups: 114 in the IG and 117 in the CG. No time-treatment effect was detected for any endpoint. The IRI and fasting insulin were significantly lower in the IG than CG after MAS (p = 0.02 & P = 0.03). The scores for anxiety, appetite, and nausea were significantly lower in the IG than CG at 1 h before MAS. Compared with baseline, the scores for appetite and nausea decreased in the IG but increased in the CG. Conclusion The oral administration of maltodextrin and fructose before MAS can improve preoperative subjective well-being and reduce postoperative insulin resistance without increasing the risk of gastrointestinal discomfort. |
| URI | http://hdl.handle.net/20.500.11897/648162 |
| ISSN | 0364-2313 |
| DOI | 10.1007/s00268-022-06455-7 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
