| Title | Changes in the prevalence of polycystic ovary syndrome in China over the past decade |
| Authors | Yang, Rui Li, Qin Zhou, Zehong Qian, Weiping Zhang, Jian Wu, Ze Jin, Lei Wu, Xueqing Zhang, Cuilian Zheng, Beihong Tan, Jichun Hao, Guimin Li, Shangwei Tian, Tian Hao, Yongxiu Zheng, Danni Wang, Yuanyuan Norman, Robert J. Li, Rong Liu, Ping Qiao, Jie |
| Affiliation | Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China Peking Univ, Key Lab Assisted Reprod, Minist Educ, Beijing 100191, Peoples R China Beijing Key Lab Reprod Endocrinol & Assisted Repro, Beijing 100191, Peoples R China Guangzhou Med Univ, Guangzhou Inst Pediat, Guangzhou Women & Childrens Med Ctr, Guangzhou 510623, Peoples R China Guangzhou Med Univer, Guangzhou Women & Childrens Med Ctr, Dept Obstet & Gynecol, Guangzhou 510623, Peoples R China Peking Univ, Dept Reprod Med, Shenzhen Hosp, Shenzhen 518036, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Dept Pathophysiol, Key Lab Cell Differentiat, Shanghai 200240, Peoples R China First People s Hosp Yunnan Prov, Dept Reprod Med, Kunming 650021, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, Wuhan 430030, Peoples R China Affiliated Hosp Shanxi Med Univ, Children Hosp Shanxi s, Reprod Med Ctr, Women Hlth Ctr Shanxi, Taiyuan 030000, Peoples R China Henan Prov People s Hosp, Reprod Med Ctr, Zhengzhou 450003, Peoples R China Fujian Med Univ, Fujian Matern & Child Hlth Hosp, Coll Clin Med Obstet & Gynecol & Pediat, Reprod Med Ctr, Fuzhou 350001, Peoples R China Shengjing Hosp China Med Univ, Ctr Reprod Med, Dept Obstet & Gynecol, Shenyang 110022, Peoples R China Hebei Med Univ, Dept Reprod Med, Hosp 2, Shijiazhuang 050000, Peoples R China West China Second Univ Hosp Sichuan Univ, Div Reprod Med Ctr, Chengdu 610041, Peoples R China Univ Adelaide, Robinson Res Inst, Discipline Obstet Gynecol, Adelaide, SA 5005, Australia |
| Keywords | REVISED 2003 CONSENSUS DIAGNOSTIC-CRITERIA COMMUNITY WOMEN EPIDEMIOLOGY |
| Issue Date | Aug-2022 |
| Publisher | LANCET REGIONAL HEALTH-WESTERN PACIFIC |
| Abstract | Background Polycystic ovary syndrome (PCOS) has become a major international public health concern. However, because of controversy about the diagnostic criteria and patient selection, estimates of its absolute prevalence and change with time vary greatly.Methods We conducted two consecutive nationwide epidemiological surveys of the prevalence of PCOS in representative samples of reproductive-aged women in China in 2010 and 2020. Face-to-face interviews were performed by trained interviewers in each survey. All participants completed a questionnaire and underwent a physical examination, blood sampling, and transvaginal pelvic ultrasound. We assessed hyperandrogenism (H), chronic anovulation (O), and polycystic ovaries (P) to classify the presence of PCOS using the Rotterdam criteria. The prevalence of PCOS among reproductive-aged women was estimated after consideration of differential probabilities of selection and population distribution. We conducted a logistic regression analysis by using the probability of PCOS as a function of the survey year to acquire the trend information across the years.Findings 28,739 respondents completed the survey, including 15,924 in the previously published 2010 survey and 12,815 in the new 2020 survey. In 2020, 826 participants could be diagnosed as having PCOS, with a weighted prevalence of 7.8% (95%CI: 7.0%, 9.0%) among women aged 20-49 years, leading to an estimate of 24.0 million women of reproductive age affected by this condition in China as a whole. The estimated prevalence in 2020 was higher than that of a decade ago despite identical research methods suggesting a two-thirds increase over the study period. Women with PCOS in 2020 also appeared to have a more severe phenotype overall than those of a decade ago, possibly reflecting a significantly higher prevalence of obesity, hyperandrogenism, and infertility.Interpretation The prevalence of PCOS in Chinese women has increased significantly over the past 10 years. PCOS is a significant public health problem in women of reproductive age in China and national policy and guidelines should be re-examined in the light of the current data.Funding National Key R&D Program of China and the National Natural Science Foundation of China.Copyright (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| URI | http://hdl.handle.net/20.500.11897/648026 |
| DOI | 10.1016/j.lanwpc.2022.100494 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 第三医院 深圳医院 |
