| Title | Risk factors for polymyxin B-associated acute kidney injury |
| Authors | Chang, Kang Wang, Haibo Zhao, Jianping Yang, Xianghong Wu, Bo Sun, Wenkui S. Huang, Man Cheng, Zhenshun Chen, Hong Song, Yuanlin Ping Chen Chen, Xiangqi Gan, Xin Ma, Wanli Xing, Lihua Wang, Yimin Cao, Bin |
| Affiliation | Capital Med Univ, China Japan Friendship Hosp, Clin Ctr Pulm Infect, Natl Clin Res Ctr Resp Dis, Beijing 100029, Peoples R China Peking Univ, Clin Res Inst, Haidian Dist, Hosp 1, 38 Xueyuan Rd, Beijing 100191, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Resp & Crit Care Med, Wuhan 430030, Peoples R China Zhejiang Prov Peoples Hosp, Peoples Hosp, Dept Intens Care Unit, Hangzhou Med Coll, Hangzhou 310014, Peoples R China Nanjing Med Univ, Dept Resp & Crit Care Med, Wuxi Peoples Hosp, Wuxi 214023, Jiangsu, Peoples R China Nanjing Med Univ, Dept Respirol & Crit Care Med, Affiliated Hosp 1, Nanjing 210029, Peoples R China Zhejiang Univ, Dept Gen Intens Care Unit, Affiliated Hosp 2, Sch Med, Hangzhou 310052, Peoples R China Wuhan Univ, Dept Pulm & Crit Care Med, Zhongnan Hosp, Wuhan 430062, Peoples R China Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Resp & Crit Care Med, Sch Med, Shanghai 200025, Peoples R China Fudan Univ, Zhongshan Hosp, Dept Pulm & Crit Care Med, Shanghai 201799, Peoples R China Cent South Univ, Xiangya Hosp 2, Dept Resp Med, Changsha 410012, Peoples R China Fujian Med Univ, Union Hosp, Dept Resp Med, Fuzhou 350001, Peoples R China Nanchang Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Resp & Crit Care Med, Wuhan 430022, Peoples R China Zhengzhou Univ, Dept Pulm & Crit Care Med, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China China Japan Friendship Hosp, Natl Clin Res Ctr Resp Dis, Dept Pulm & Crit Care Med, China Ctr Resp Med,Inst Resp Med, 2 East Yinghua Rd, Beijing 100029, Peoples R China China Japan Friendship Hosp, China Ctr Resp Med, Natl Clin Res Ctr Resp Dis, Dept Pulm & Crit Care Med, Beijing 100029, Peoples R China Chinese Acad Med Sci, Peking Union Med Coll, Inst Resp Med, Beijing 100029, Peoples R China Capital Med Univ, Dept Resp Med, Beijing 100029, Peoples R China Tsinghua Univ, Sch Med, Beijing 100029, Peoples R China |
| Keywords | RENAL-FAILURE COLISTIN DISEASE NEPHROTOXICITY MORTALITY COLISTIMETHATE INFECTIONS EFFICACY SEPSIS SAFETY |
| Issue Date | Apr-2022 |
| Publisher | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES |
| Abstract | Objectives: This study aimed to assess the current incidence and risk factors for polymyxin B-associated acute kidney injury (AKI) in Chinese hospitals for a more effective clinical use for polymyxin B. Methods: This multicenter, retrospective cohort study included patients from 14 Chinese teaching hospitals who received polymyxin B therapy. Univariate and multivariate logistic regression models were used to determine the factors associated with polymyxin B-associated incident AKI. Furthermore, a multivariate logistic regression model was used to identify the independent risk factors for AKI. Results: A total of 251 patients were included in the analysis. The overall incidence of AKI was 33.5%. A multivariate logistic regression model identified the loading dose (hazard ratio (HR), 1.84; 95% confidence interval (CI), 1.01-3.38; P = 0.0491) and the use of two or more nephrotoxic drugs (HR, 3.56; 95% CI, 1.55-8.18; P = 0.0029) as independent risk factors for the occurrence of AKI. Meanwhile, the estimated glomerular filtration rate had a protective effect (HR, 0.99; 95% CI, 0.98-0.99; P = 0.0 0 06) on the occurrence of AKI. The daily dose, cumulative dose, and treatment duration of polymyxin B did not affect the occurrence of AKI.Conclusions: The use of polymyxin B loading doses and the combined use of multiple nephrotoxic drugs are independent risk factors for polymyxin B-associated AKI. The severity of AKI may be higher in patients with elevated baseline creatinine levels.(c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| URI | http://hdl.handle.net/20.500.11897/647637 |
| ISSN | 1201-9712 |
| DOI | 10.1016/j.ijid.2022.01.055 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
