| Title | Loss of the Sympathetic Signal Produces Sterile Inflammation of the Prostate |
| Authors | Hu, Hao Cui, Yiwen Yang, Jing Cao, Ying |
| Affiliation | Peking Univ, Dept Urol, Peoples Hosp, Beijing, Peoples R China Peking Univ, Tsinghua Univ, Natl Inst Biol Sci Joint Grad Program, Beijing, Peoples R China Peking Univ, Acad Adv Interdisciplinary Studies, Beijing, Peoples R China Shenzhen Bay Lab, Shenzhen, Peoples R China Peking Univ, Ctr Life Sci, Beijing, Peoples R China |
| Keywords | PELVIC PAIN SYNDROME AUTOIMMUNE PROSTATITIS SMOOTH-MUSCLE INNERVATION GROWTH NERVES GLAND |
| Issue Date | 10-May-2022 |
| Publisher | FRONTIERS IN MOLECULAR NEUROSCIENCE |
| Abstract | Neural innervations exert essential roles in the prostate. However, spatial distribution and regulatory function of such neural inputs are incompletely characterized. Here, we exploited the advanced whole-tissue immunolabeling and optical clearing technique to assess the 3D anatomy of autonomic innervations in the mouse and human prostate for the first time. We observed that sympathetic and parasympathetic inputs in the mouse prostate remained unaffected during castration-induced tissue regression. However, the pharmacologic destruction of sympathetic innervations in the mouse prostate led to sterile inflammation of the tissue, mimicking the disease condition of chronic non-bacterial prostatitis. Also, the genetic ablation of sympathetic inputs produced a similar inflammatory response. Furthermore, we showed that treatment of the specific beta 2-adrenergic receptor agonists could effectively mitigate the prostate inflammation caused by such sympathetic loss. Together, these results have elucidated the new immunomodulatory function of the sympathetic signal via the beta 2-adrenergic receptor in prostate inflammatory disease. |
| URI | http://hdl.handle.net/20.500.11897/647330 |
| ISSN | 1662-5099 |
| DOI | 10.3389/fnmol.2022.855376 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 生命科学学院 前沿交叉学科研究院 |
