| Title | CMV infection combined with acute GVHD associated with poor CD8+T-cell immune reconstitution and poor prognosis post-HLA-matched allo-HSCT |
| Authors | Fan, Ze-Ying Han, Ting-Ting Zuo, Wei Zhao, Xiao-Su Chang, Ying-Jun Lv, Meng Mo, Xiao-Dong Sun, Yu-Qian Zhang, Yuan-Yuan Wang, Yu Xu, Lan-Ping Zhang, Xiao-Hui Liu, Kai-Yan Huang, Xiao-Jun Zhao, Xiang-Yu |
| Affiliation | Peking Univ, Peking Univ Peoples Hosp, Natl Clin Res Ctr Hematol Dis,Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, 11 Xizhimen South St, Beijing 100044, Peoples R China Collaborat Innovat Ctr Hematol, Beijing 100044, Peoples R China |
| Keywords | HEMATOPOIETIC-CELL TRANSPLANTATION CORD BLOOD TRANSPLANTATION T-CELLS CYTOMEGALOVIRUS SURVIVAL OUTCOMES MULTICENTER PREDICTOR MORTALITY EXPOSURE |
| Issue Date | May-2022 |
| Publisher | CLINICAL AND EXPERIMENTAL IMMUNOLOGY |
| Abstract | Cytomegalovirus (CMV) infection and acute graft-versus-host disease (aGVHD) are two major complications that contribute to a poor prognosis after hematopoietic stem cell transplantation (HSCT). Superior early immune reconstitution (IR) is associated with improved survival after HSCT. However, when all three factors, CMV infection, aGVHD, and IR, are concomitantly considered, the effects of the triple events on HSCT are still unknown and should be studied further. Thus we enrolled 185 patients who were diagnosed as hematological malignancies and treated with HLA-matched sibling transplantation (MST) between January 2010 and December 2014, of whom 83 were positive for CMV infection and 82 had aGVHD. Results showed that patients with both aGVHD and CMV infection had significantly higher non-relapse mortality (NRM), lower overall survival (OS), and delayed CD8+ T-cell IR. Multivariate analyses showed that both aGVHD combined with CMV infection and delayed CD8+ T-cell IR were independent risk factors for prognosis post-MST. Recurrent CMV infections are associated with poor CD8+ T-cell reconstitution. However, superior IR could protect against the negative effects of aGVHD and CMV infection on the transplant outcomes. Co-occurrence of aGVHD and CMV infection significantly affect the outcomes of HLA-matched sibling hematopoietic stem cell transplantation. However, superior immune reconstitution (IR) could protect against the negative effects of aGVHD and CMV infection (double positive, DP) on the transplant outcomes. |
| URI | http://hdl.handle.net/20.500.11897/647189 |
| ISSN | 0009-9104 |
| DOI | 10.1093/cei/uxac047 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
