| Title | Deciphering mechanism of the herbal formula WuShen in the treatment of postinfarction heart failure |
| Authors | Qiu, Huiliang Huang, Zeng-Yan Cao, Haiming Zhang, Zezhao Ma, Jin Li, Xiao-Qing Huang, Shen Li, Xiong Qiu, Wencong Zhao, Zicong Ji, Chunlan Huang, Lihua Jiang, Wei Yang, Zhong-Qi Xian, Shao-Xiang Wu, Huanlin Lu, Weihui Ding, Chunhua |
| Affiliation | Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510006, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Dept Cardiol, Guangzhou 510120, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou 510120, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Peoples R China Guangzhou Univ Chinese Med, Lingnan Med Res Ctr, Guangzhou 510405, Peoples R China Chengdu Univ, Affiliated Hosp, Dept Cardiol, Chengdu 610081, Peoples R China Guangzhou Univ Chinese Med, Foshan Hosp Tradit Chinese Med, Foshan 528000, Peoples R China Beijing Univ Chinese Med, Dept Internal Med, Beijing 100000, Peoples R China Guangdong Prov Key Lab Chinese Med Prevent & Trea, Guangzhou 510020, Peoples R China Peking Univ, Aerosp Sch Clin Med, Aerosp Ctr Hosp, Cardiac Dept, 15 Yuquan Rd, Beijing 100049, Peoples R China Univ Calif San Francisco, Div Cardiol, San Francisco, CA 94143 USA |
| Keywords | ACUTE MYOCARDIAL-INFARCTION REDUCES ATRIAL-FIBRILLATION SUSCEPTIBILITY RATS OVERLOAD FIBROSIS THERAPY |
| Issue Date | Jan-2022 |
| Publisher | PHYTOMEDICINE |
| Abstract | Background: Numerous clinical studies reported the effectiveness of herbal formula WuShen (WS) in treating cardiovascular diseases, yet relevant basic research was rarely conducted. Methods and results: Twelve main bioactive compounds of WS decoction were identified using the ultraperformance liquid chromatography-LTQ-Orbitrap mass spectrometer. A total of 137 active compounds with 613 targets were predicted by network pharmacology; their bioinformatic annotation and human micmarray data suggested that wounding healing, inflammatory response, and gap junction were potentially the major therapeutic modules. A rat model of post-myocardial infarction (MI) heart failure (HF) was used to study the effects of WS on cardiac function, adverse cardiac remodeling, and experimental arrhythmias. Rats treated with WS led to a significantly improved pump function and reduced susceptibility to both ventricular tachycardia and atrial fibrillation, and restricted adverse cardiac remodeling partly via inhibiting TGF beta 1/SMADs mediated extracellular matrix deposition and Rac1/NOX2/CTGF/Connexin43 -involved gap junction remodeling. Conclusions: The present study highlights that WS can be applied to the treatment of heart failure and the upstream therapy for atrial fibrillation and ventricular tachycardia through its preventive effect on adverse cardiac remodeling. |
| URI | http://hdl.handle.net/20.500.11897/646758 |
| ISSN | 0944-7113 |
| DOI | 10.1016/j.phymed.2021.153878 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京航天中心医院 |
