| Title | Association of nanoparticle exposure with serum metabolic disorders of healthy adults in printing centers |
| Authors | Jia, Shenglan Setyawati, Magdiel Inggrid Liu, Min Xu, Tengfei Loo, Joachim Yan, Meilin Gong, Jicheng Chotirmall, Sanjay H. Demokritou, Philip Ng, Kee Woei Fang, Mingliang |
| Affiliation | Nanyang Technol Univ, Sch Civil & Environm Engn, 50 Nanyang Ave, Singapore 639798, Singapore Nanyang Technol Univ, Nanyang Environm & Water Res Inst NEWRI, 1 Cleantech Loop,CleanTech One, Singapore 637141, Singapore Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 639798, Singapore Harvard Univ, Ctr Nanotechnol & Nanotoxicol, TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA Fudan Univ, Dept Environm Sci & Engn, Shanghai 200433, Peoples R China |
| Keywords | TITANIUM-DIOXIDE NANOPARTICLES EMITTED ENGINEERED NANOPARTICLES SHORT-TERM EXPOSURE OXIDATIVE STRESS QUANTITATIVE BIOKINETICS PHOTOCOPIER OPERATORS INFLAMMATION CELLS ARGININE PARTICLES |
| Issue Date | 15-Jun-2022 |
| Publisher | JOURNAL OF HAZARDOUS MATERIALS |
| Abstract | Printers are everyday devices in both our homes and workplaces. We have previously found high occupational exposure levels to toner-based printer emitted nanoparticles (PEPs) at printing centers. To elucidate the potential health effects from exposure to PEPs, a total of 124 human serum samples were collected from 32 workers in the printing centers during the repeated follow-up measurements, and global serum metabolomics were analyzed in three ways: correlation between metabolic response and personal exposure (dose response exposure); metabolite response changes between Monday and Friday of a work week (short-term exposure), and metabolite response in relation to length of service in a center (long-term exposure). A total of 52 key metabolites changed significantly in relation to nanoparticle exposure levels. The primary dysregulated pathways included inflammation and immunity related arginine and tryptophan metabolism. Besides, some distinct metabolite expression patterns were found to occur during the transition from short-term to long-term exposures, suggesting cumulative effect of PEPs exposure. These findings, for the first time, highlight the inhalation exposure responses to printer emitted nanoparticles at the metabolite level, potentially serving as pre-requisites for whole organism and population responses, and are inline with emerging findings on potential health effects. |
| URI | http://hdl.handle.net/20.500.11897/643442 |
| ISSN | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2022.128710 |
| Indexed | SCI(E) |
| Appears in Collections: | 环境科学与工程学院 |
