| Title | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation |
| Authors | Mahajan, Anubha Spracklen, Cassandra N. Zhang, Weihua Ng, Maggie C. Y. Petty, Lauren E. Kitajima, Hidetoshi Yu, Grace Z. Rueger, Sina Speidel, Leo Kim, Young Jin Horikoshi, Momoko Mercader, Josep M. Taliun, Daniel Moon, Sanghoon Kwak, Soo-Heon Robertson, Neil R. Rayner, Nigel W. Loh, Marie Kim, Bong-Jo Chiou, Joshua Miguel-Escalada, Irene Parolo, Pietro della Briotta Lin, Kuang Bragg, Fiona Preuss, Michael H. Takeuchi, Fumihiko Nano, Jana Guo, Xiuqing Lamri, Amel Nakatochi, Masahiro Scott, Robert A. Lee, Jung-Jin Huerta-Chagoya, Alicia Graff, Mariaelisa Chai, Jin-Fang Parra, Esteban J. Yao, Jie Bielak, Lawrence F. Tabara, Yasuharu Hai, Yang Steinthorsdottir, Valgerdur Cook, James P. Kals, Mart Grarup, Niels Schmidt, Ellen M. Pan, Ian Sofer, Tamar Wuttke, Matthias Sarnowski, Chloe Gieger, Christian Nousome, Darryl Trompet, Stella Long, Jirong Sun, Meng Tong, Lin Chen, Wei-Min Ahmad, Meraj Noordam, Raymond Lim, Victor J. Y. Tam, Claudia H. T. Joo, Yoonjung Yoonie Chen, Chien-Hsiun Raffield, Laura M. Lecoeur, Cecile Prins, Bram Peter Nicolas, Aude Yanek, Lisa R. Chen, Guanjie Jensen, Richard A. Tajuddin, Salman Kabagambe, Edmond K. An, Ping Xiang, Anny H. Choi, Hyeok Sun Cade, Brian E. Tan, Jingyi Flanagan, Jack Abaitua, Fernando Adair, Linda S. Adeyemo, Adebowale Aguilar-Salinas, Carlos A. Akiyama, Masato Anand, Sonia S. Bertoni, Alain Bian, Zheng Bork-Jensen, Jette Brandslund, Ivan Brody, Jennifer A. Brummett, Chad M. Buchanan, Thomas A. Canouil, Mickael Chan, Juliana C. N. Chang, Li-Ching Chee, Miao-Li Chen, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengming Chuang, Lee-Ming Cushman, Mary Das, Swapan K. de Silva, H. Janaka Dedoussis, George Dimitrov, Latchezar Doumatey, Ayo P. Du, Shufa Duan, Qing Eckardt, Kai-Uwe Emery, Leslie S. Evans, Daniel S. Evans, Michele K. Fischer, Krista Floyd, James S. Ford, Ian Fornage, Myriam Franco, Oscar H. Frayling, Timothy M. Freedman, Barry, I Fuchsberger, Christian Genter, Pauline Gerstein, Hertzel C. Giedraitis, Vilmantas Gonzalez-Villalpando, Clicerio Gonzalez-Villalpando, Maria Elena Goodarzi, Mark O. Gordon-Larsen, Penny Gorkin, David Gross, Myron Guo, Yu Hackinger, Sophie Han, Sohee Hattersley, Andrew T. Herder, Christian Howard, Annie-Green Hsueh, Willa Huang, Mengna Huang, Wei Hung, Yi-Jen Hwang, Mi Yeong Hwu, Chii-Min Ichihara, Sahoko Ikram, Mohammad Arfan Ingelsson, Martin Islam, Md Tariqul Isono, Masato Jang, Hye-Mi Jasmine, Farzana Jiang, Guozhi Jonas, Jost B. Jorgensen, Marit E. Jorgensen, Torben Kamatani, Yoichiro Kandeel, Fouad R. Kasturiratne, Anuradhani Katsuya, Tomohiro Kaur, Varinderpal Kawaguchi, Takahisa Keaton, Jacob M. Kho, Abel N. Khor, Chiea-Chuen Kibriya, Muhammad G. Kim, Duk-Hwan Kohara, Katsuhiko Kriebel, Jennifer Kronenberg, Florian Kuusisto, Johanna Lall, Kristi Lange, Leslie A. Lee, Myung-Shik Lee, Nanette R. Leong, Aaron Li, Liming Li, Yun Li-Gao, Ruifang Ligthart, Symen Lindgren, Cecilia M. Linneberg, Allan Liu, Ching-Ti Liu, Jianjun Locke, Adam E. Louie, Tin Luan, Jian'an Luk, Andrea O. Luo, Xi Lv, Jun Lyssenko, Valeriya Mamakou, Vasiliki Mani, K. Radha Meitinger, Thomas Metspalu, Andres Morris, Andrew D. Nadkarni, Girish N. Nadler, Jerry L. Nalls, Michael A. Nayak, Uma Nongmaithem, Suraj S. Ntalla, Ioanna Okada, Yukinori Orozco, Lorena Patel, Sanjay R. Pereira, Mark A. Peters, Annette Pirie, Fraser J. Porneala, Bianca Prasad, Gauri Preissl, Sebastian Rasmussen-Torvik, Laura J. Reiner, Alexander P. Roden, Michael Rohde, Rebecca Roll, Kathryn Sabanayagam, Charumathi Sander, Maike Sandow, Kevin Sattar, Naveed Schonherr, Sebastian Schurmann, Claudia Shahriar, Mohammad Shi, Jinxiu Shin, Dong Mun Shriner, Daniel Smith, Jennifer A. So, Wing Yee Stancakova, Alena Stilp, Adrienne M. Strauch, Konstantin Suzuki, Ken Takahashi, Atsushi Taylor, Kent D. Thorand, Barbara Thorleifsson, Gudmar Thorsteinsdottir, Unnur Tomlinson, Brian Torres, Jason M. Tsai, Fuu-Jen Tuomilehto, Jaakko Tusie-Luna, Teresa Udler, Miriam S. Valladares-Salgado, Adan van Dam, Rob M. van Klinken, Jan B. Varma, Rohit Vujkovic, Marijana Wacher-Rodarte, Niels Wheeler, Eleanor Whitsel, Eric A. Wickremasinghe, Ananda R. van Dijk, Ko Willems Witte, Daniel R. Yajnik, Chittaranjan S. Yamamoto, Ken Yamauchi, Toshimasa Yengo, Loic Yoon, Kyungheon Yu, Canqing Yuan, Jian-Min Yusuf, Salim Zhang, Liang Zheng, Wei Raffel, Leslie J. Igase, Michiya Ipp, Eli Redline, Susan Cho, Yoon Shin Lind, Lars Province, Michael A. Hanis, Craig L. Peyser, Patricia A. Ingelsson, Erik Zonderman, Alan B. Psaty, Bruce M. Wang, Ya-Xing Rotimi, Charles N. Becker, Diane M. Matsuda, Fumihiko Liu, Yongmei Zeggini, Eleftheria Yokota, Mitsuhiro Rich, Stephen S. Kooperberg, Charles Pankow, James S. Engert, James C. Chen, Yii-Der Ida Froguel, Philippe Wilson, James G. Sheu, Wayne H. H. Kardia, Sharon L. R. Wu, Jer-Yuarn Hayes, M. Geoffrey Ma, Ronald C. W. Wong, Tien-Yin Groop, Leif Mook-Kanamori, Dennis O. Chandak, Giriraj R. Collins, Francis S. Bharadwaj, Dwaipayan Pare, Guillaume Sale, Michele M. Ahsan, Habibul Motala, Ayesha A. Shu, Xiao-Ou Park, Kyong-Soo Jukema, J. Wouter Cruz, Miguel McKean-Cowdin, Roberta Grallert, Harald Cheng, Ching-Yu Bottinger, Erwin P. Dehghan, Abbas Tai, E-Shyong Dupuis, Josee Kato, Norihiro Laakso, Markku Kottgen, Anna Koh, Woon-Puay Palmer, Colin N. A. Liu, Simin Abecasis, Goncalo Kooner, Jaspal S. Loos, Ruth J. F. North, Kari E. Haiman, Christopher A. Florez, Jose C. Saleheen, Danish Hansen, Torben Pedersen, Oluf Magi, Reedik Langenberg, Claudia Wareham, Nicholas J. Maeda, Shiro Kadowaki, Takashi Lee, Juyoung Millwood, Iona Y. Walters, Robin G. Stefansson, Kari Myers, Simon R. Ferrer, Jorge Gaulton, Kyle J. Meigs, James B. Mohlke, Karen L. Gloyn, Anna L. Bowden, Donald W. Below, Jennifer E. Chambers, John C. Sim, Xueling Boehnke, Michael Rotter, Jerome, I McCarthy, Mark, I Morris, Andrew P. |
| Affiliation | Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England Univ North Carolina Chapel Hill, Dept Genet, Chapel Hill, NC USA Univ Massachusetts, Dept Epidemiol & Biostat, Amherst, MA 01003 USA Imperial Coll London, Dept Epidemiol & Biostat, London, England London North West Healthcare NHS Trust, Dept Cardiol, Ealing Hosp, London, England Vanderbilt Univ Sch Med, Vanderbilt Genet Inst, Div Genet Med, Nashville, TN USA Wake Forest Sch Med, Ctr Genom & Personalized Med Res, Winston Salem, NC 27101 USA Wake Forest Sch Med, Dept Biochem, Winston Salem, NC 27101 USA Tohoku Univ, Adv Res Ctr Innovat Next Generat Med INGEM, Sendai, Miyagi, Japan Tohoku Univ, Dept Integrat Genom, Tohoku Med Megabank Org, Sendai, Miyagi, Japan Tohoku Univ, Tohoku Univ Hosp, Canc Ctr, Sendai, Miyagi, Japan Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland UCL, Genet Inst, London, England Francis Crick Inst, London, England Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Cheongju, South Korea RIKEN Ctr Integrat Med Sci, Lab Genom Diabet & Metab, Yokohama, Kanagawa, Japan Broad Inst Harvard & MIT, Programs Metab, Cambridge, MA USA Broad Inst Harvard & MIT, Program Med, Cambridge, MA USA Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA Harvard Med Sch, Boston, MA 02115 USA Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea Wellcome Sanger Inst, Dept Human Genet, Hinxton, England Helmholtz Zentrum Munchen, Inst Translat Genom, German Res Ctr Environm Hlth, Neuherberg, Germany Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore ASTAR, Translat Lab Genet Med TLGM, Singapore, Singapore Natl Univ Singapore NUS, Singapore, Singapore Univ Calif San Diego, Biomed Sci Grad Studies Program, La Jolla, CA 92093 USA Barcelona Inst Sci & Technol, Ctr Genom Regulat, Regulatory Genom & Diabet, Barcelona, Spain Ctr Invest Biomed Red Diabet & Enfermed Metabol A, Madrid, Spain Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo, Japan Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Los Angeles Biomed Res Inst,Inst Translat Genom &, Torrance, CA 90509 USA McMaster Univ, Dept Med, Hamilton, ON, Canada Hamilton Hlth Sci & McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada Nagoya Univ, Dept Integrated Hlth Sci, Publ Hlth Informat Unit, Grad Sch Med, Nagoya, Aichi, Japan Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England Univ Penn, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Consejo Nacl Ciencia & Tecnol CONACYT, Mexico City, DF, Mexico Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore Natl Univ Hlth Syst, Singapore, Singapore Univ Toronto Mississauga, Dept Anthropol, Mississauga, ON, Canada Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan Amgen Inc, deCODE Genet, Reykjavik, Iceland Univ Liverpool, Dept Hlth Data Sci, Liverpool, Merseyside, England Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark Brown Univ, Dept Epidemiol, Sch Publ Hlth, Providence, RI 02912 USA Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA Brigham & Womens Hosp, Div Sleep & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA Harvard Univ, Dept Med, Boston, MA 02115 USA Univ Freiburg, Fac Med, Inst Genet Epidemiol, Dept Data Driven Med, Freiburg, Germany Univ Freiburg, Med Ctr, Freiburg, Germany Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA German Ctr Diabet Res DZD, Neuherberg, Germany Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany USC, Dept Populat & Publ Hlth Sci, Keck Sch Med, Los Angeles, CA USA Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands Leiden Univ Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands Vanderbilt Univ Sch Med, Inst Med & Publ Hlth, Vanderbilt Genet Inst, Dept Med, Nashville, TN USA Univ Chicago, Inst Populat & Precis Hlth, Chicago, IL 60637 USA Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA CSIR Ctr Cellular & Mol Biol CSIR CCMB, Genom Res Complex Dis GRC Grp, Hyderabad, India Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China Chinese Univ Hong Kong, Chinese Univ Hong Kong Shanghai Jiao Tong Univ Jo, Hong Kong, Peoples R China Northwestern Univ, Dept Med, Div Endocrinol Metab & Mol Med, Feinberg Sch Med, Chicago, IL 60611 USA Northwestern Univ, Dept Hlth & Biomed Informat, Feinberg Sch Med, Chicago, IL 60611 USA Acad Sinica, Inst Biomed Sci, Taipei, Taiwan Inst Pasteur, European Genom Inst Diabet, Inserm U1283, CNRS UMR 8199, Lille, France Univ Lille, Lille Univ Hosp, Lille, France NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA Washington Univ, Sch Med, Div Stat Genom, St Louis, MO USA Kaiser Permanente Southern Calif, Div Biostat Res, Dept Res & Evaluat, Pasadena, CA USA Hallym Univ, Dept Biomed Sci, Chunchon, South Korea Univ North Carolina Chapel Hill, Dept Nutr, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Invest Enfermedades Metab & Dept Endocrino, Mexico City, DF, Mexico RIKEN Ctr Integrat Med Sci, Lab Stat & Translat Genet, Yokohama, Kanagawa, Japan Kyushu Univ, Grad Sch Med Sci, Dept Ocular Pathol & Imaging Sci, Fukuoka, Japan McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada Wake Forest Sch Med, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Winston Salem, NC 27101 USA Chinese Acad Med Sci, Beijing, Peoples R China Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark Vejle Hosp, Dept Clin Biochem, Vejle, Denmark Univ Michigan, Dept Anesthesiol, Med Sch, Ann Arbor, MI 48109 USA USC, Dept Med, Div Endocrinol & Diabet, Keck Sch Med, Los Angeles, CA USA Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore Wellcome Sanger Inst, Hinxton, England Wake Forest Sch Med, Dept Biostat & Data Sci, Winston Salem, NC 27101 USA Natl Taiwan Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Taipei, Taiwan Univ Vermont, Dept Med, Colchester, VT USA Wake Forest Sch Med, Dept Internal Med, Sect Endocrinol & Metab, Winston Salem, NC 27101 USA Univ Kelaniya, Fac Med, Dept Med, Ragama, Sri Lanka Harokopio Univ Athens, Dept Nutr & Dietet, Athens, Greece Univ North Carolina Chapel Hill, Carolina Populat Ctr, Chapel Hill, NC USA Charite Univ Med Berlin, Dept Nephrol & Med Intens Care Med, Berlin, Germany Friedrich Alexander Univ Erlangen Nurnberg, Dept Nephrol & Hypertens, Erlangen, Germany Univ Washington, Dept Biostat, Seattle, WA 98195 USA Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX 77030 USA Univ Exeter, Univ Exeter Med Sch, Genet Complex Traits, Exeter, Devon, England Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC 27101 USA Univ Lubeck, Affiliated Inst, Inst Biomed, Eurac Res, Bolzano, Italy Harbor UCLA Med Ctr, Lundquist Res Inst, Div Endocrinol & Metab, Dept Med, Torrance, CA 90509 USA Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Unidad Invest Diabet & Riesgo Cardiovasc, Ctr Estudios Diabet, Mexico City, DF, Mexico Cedars Sinai Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA Univ Calif San Diego, Ctr Epigen, La Jolla, CA 92093 USA Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA Univ Exeter, Univ Exeter Med Sch, Exeter, Devon, England Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Med Fac, Dept Endocrinol & Diabetol, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany Univ North Carolina Chapel Hill, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA Ohio State Univ, Dept Internal Med, Diabet & Metab Res Ctr, Wexner Med Ctr, Columbus, OH 43210 USA Brown Univ, Ctr Global Cardiometab Hlth, Providence, RI 02912 USA Chinese Natl Human Genome Ctr Shanghai CHGC, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai, Peoples R China Shanghai Inst Biomed & Pharmaceut Technol SIBPT, Shanghai, Peoples R China Triserv Gen Hosp Songshan Branch, Div Endocrine & Metab, Taipei, Taiwan Natl Def Med Ctr, Sch Med, Taipei, Taiwan Taipei Vet Gen Hosp, Dept Med, Sect Endocrinol & Metab, Taipei, Taiwan Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei, Taiwan Jichi Med Univ, Dept Environm & Prevent Med, Sch Med, Shimotsuke, Tochigi, Japan Univ Chicago Res Bangladesh, Dhaka, Bangladesh Inst Mol & Clin Ophthalmol Basel, Basel, Switzerland Steno Diabet Ctr Copenhagen, Gentofte, Denmark Southern Denmark Univ, Natl Inst Publ Hlth, Copenhagen, Denmark Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Frederiksberg, Denmark Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark Aalborg Univ, Fac Med, Aalborg, Denmark Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Complex Trait Genom, Tokyo, Japan City Hope Natl Med Ctr, Dept Translat Res & Cellular Therapeut, Dept Clin Diabet Endocrinol & Metab, Duarte, CA USA Univ Kelaniya, Fac Med, Dept Publ Hlth, Ragama, Sri Lanka Osaka Univ, Dept Clin Gene Therapy, Grad Sch Med, Osaka, Japan Osaka Univ, Grad Sch Med, Dept Geriatr & Gen Med, Osaka, Japan Northwestern Univ, Dept Med, Div Gen Internal Med & Geriatr, Feinberg Sch Med, Chicago, IL 60611 USA Northwestern Univ, Ctr Hlth Informat Partnerships, Inst Publ Hlth & Med, Feinberg Sch Med, Chicago, IL 60611 USA Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore Sungkyunkwan Univ, Dept Mol Cell Biol, Sch Med, Suwon, South Korea Ehime Univ, Dept Reg Resource Management, Fac Collaborat Reg Innovat, Matsuyama, Ehime, Japan Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland Kuopio Univ Hosp, Kuopio, Finland Univ Tartu, Inst Math & Stat, Tartu, Estonia Univ Colorado Denver, Dept Med, Anschutz Med Campus, Aurora, CO USA Yonsei Univ, Severance Biomed Sci Inst, Coll Med, Seoul, South Korea Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea Univ San Carlos, USC Off Populat Studies Fdn Inc, Cebu, Philippines Harvard Med Sch, Dept Med, Boston, MA 02115 USA Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA Peking Univ, Peking Univ Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing, Peoples R China Leiden Univ Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands Broad Inst, Program Med & Populat Genet, Cambridge, MA USA Univ Oxford, Li Ka Shing Ctr Hlth Informat & Discovery, Big Data Inst, Oxford, England Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA Washington Univ, Dept Med, Div Genom & Bioinformat, Sch Med, St Louis, MO USA Univ Texas Hlth Sci Ctr Houston, Dept Biostat & Data Sci, Houston, TX 77030 USA Lund Univ, Dept Clin Sci Diabet & Endocrinol, Diabet Ctr, Malmo, Sweden Univ Bergen, Ctr Diabet Res, Dept Clin Sci, Bergen, Norway Natl & Kapodistrian Univ Athens, Dromokaiteio Psychiat Hosp, Athens, Greece Helmholtz Zentrum Munchen, Inst Human Genet, German Res Ctr Environm Hlth, Neuherberg, Germany Tech Univ Munich, Inst Human Genet, Munich, Germany German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland Hasso Plattner Inst, Digital Hlth Ctr, Digital Engn Fac, Potsdam, Germany Univ Potsdam, Potsdam, Germany Icahn Sch Med Mt Sinai, Div Data Driven & Digital Med D3M, Dept Med, New York, NY 10029 USA New York Med Coll, Dept Med & Pharmacol, Valhalla, NY 10595 USA Data Tecn Int LLC, Glen Echo, MD USA NIH, Ctr Alzheimers & Related Dementias, Baltimore, MD USA Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan Osaka Univ, Immunol Frontier Res Ctr WPI IFReC, Lab Stat Immunol, Osaka, Japan RIKEN Ctr Integrat Med Sci, Lab Syst Genet, Yokohama, Kanagawa, Japan Inst Nacl Med Genom, Mexico City, DF, Mexico Univ Pittsburgh, Dept Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA Univ KwaZulu Natal, Coll Hlth Sci, Nelson R Mandela Sch Med, Dept Diabet & Endocrinol, Durban, South Africa Acad Sci & Innovat Res, CSIR Human Resource Dev Ctr Campus, Ghaziabad, India CSIR Inst Genom & Integrat Biol, Genom & Mol Med Unit, New Delhi, India Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore Univ Calif San Diego, Dept Pediat, Pediat Diabet Res Ctr, La Jolla, CA 92093 USA Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland Icahn Sch Med Mt Sinai, Hasso Plattner Inst, Digital Hlth Mt Sinai, New York, NY 10029 USA Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA Helmholtz Zentrum Munchen, Inst Genet Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany Ludwig Maximilians Univ Munchen, Fac Med, IBE, Chair Genet Epidemiol, Munich, Germany Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Mainz, Germany Univ Tokyo, Grad Sch Med, Dept Diabet & Metab Dis, Tokyo, Japan Natl Cerebral & Cardiovasc Ctr, Dept Genom Med, Osaka, Japan Univ Reykjavik, Fac Med, Reykjavik, Iceland Macau Univ Sci & Technol, Fac Med, Macau, Peoples R China China Med Univ Hosp, Dept Med Genet & Med Res, Taichung, Taiwan Finnish Inst Hlth & Welf, Dept Hlth, Helsinki, Finland Natl Sch Publ Hlth, Madrid, Spain Danube Univ Krems, Dept Neurosci & Prevent Med, Krems, Austria King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Biol Mol & Med Genom, Mexico City, DF, Mexico Univ Nacl Autonoma Mexico, Dept Med Genom & Toxiol, Ambiental Inst Invest Biomed, Mexico City, DF, Mexico IMSS, Hosp Especialidades, Ctr Med Nacl Siglo 21, Unidad Invest Med Bioquim, Mexico City, DF, Mexico Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands Leiden Univ Med Ctr, Dept Human Genet, Leiden, Netherlands Amsterdam Univ Med Ctr, Dept Clin Chem, Lab Genet Metab Dis, Amsterdam, Netherlands CHA Hollywood Presbyterian Med Ctr, Southern Calif Eye Inst, Los Angeles, CA USA Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA IMSS, Ctr Med Nacl Siglo 21, Hosp Especialidades, Unidad Invest Med Epidemiol Clin, Mexico City, DF, Mexico Univ North Carolina Chapel Hill, Dept Med, Sch Med, Chapel Hill, NC USA Leiden Univ Med Ctr, Dept Internal Med, Div Endocrinol, Leiden, Netherlands Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark Danish Diabet Acad, Odense, Denmark King Edward Mem Hosp & Res Ctr, Diabetol Res Ctr, Pune, Maharashtra, India Kurume Univ, Dept Med Biochem, Sch Med, Kurume, Fukuoka, Japan Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, Pittsburgh, PA USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA UCI Irvine Sch Med, Dept Pediat, Div Genet & Genom Med, Irvine, CA USA Ehime Univ, Dept Antiaging Med, Grad Sch Med, Matsuyama, Ehime, Japan Beth Israel Deaconess Med Ctr, Div Pulm Crit Care & Sleep Med, Boston, MA 02215 USA Uppsala Univ, Dept Med Sci, Uppsala, Sweden Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Houston, TX 77030 USA Stanford Univ, Div Cardiovasc Med, Dept Med, Sch Med, Stanford, CA 94305 USA Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA Capital Med Univ, Beijing Tongren Hosp, Beijing Inst Ophthalmol, Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China Duke Univ, Sch Med, Dept Med, Div Cardiol, Durham, NC 27706 USA Tech Univ Munich TUM, Munich, Germany TUM Sch Med, Klinikum Rechts Isar, Munich, Germany Kurume Univ, Sch Med, Kurume, Fukuoka, Japan McGill Univ, Dept Med, Montreal, PQ, Canada McGill Univ, Dept Human Genet, Montreal, PQ, Canada Imperial Coll London, Sch Publ Hlth, Dept Genom Common Dis, London, England Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA Taichung Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, Taichung, Taiwan Northwestern Univ, Feinberg Sch Med, Ctr Genet Med, Chicago, IL 60611 USA Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA NHGRI, Ctr Precis Hlth Res, NIH, Bethesda, MD 20892 USA Jawaharlal Nehru Univ, Sch Biotechnol, Syst Genom Lab, New Delhi, India McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea Netherlands Heart Inst, Utrecht, Netherlands Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England Duke NUS Med Sch, Singapore, Singapore ASTAR, Singapore Inst Clin Sci, Singapore, Singapore Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Programme, Singapore, Singapore Univ Dundee, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Dundee, Scotland Brown Univ, Dept Med, Alpert Sch Med, Providence, RI 02912 USA Imperial Coll Healthcare NHS Trust, Imperial Coll London, London, England Imperial Coll London, Natl Heart & Lung Inst, London, England Ichan Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY USA Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA Ctr Noncommunicable Dis, Karachi, Pakistan Charite, Computat Med, Berlin Inst Hlth, Berlin, Germany Univ Ryukyus, Grad Sch Med, Dept Adv Genom & Lab Med, Nishihara, Okinawa, Japan Univ Ryukyus Hosp, Div Clin Lab & Blood Transfus, Nishihara, Okinawa, Japan Univ Oxford, Dept Stat, Oxford, England Imperial Coll London, Dept Metab Digest & Reprod, Sect Genet & Genom, London, England Oxford Univ Hosp NHS Fdn Trust, Churchill Hosp, Oxford NIHR Biomed Res Ctr, Oxford, England Stanford Univ, Div Endocrinol, Dept Pediat, Stanford Sch Med, Stanford, CA 94305 USA Wake Forest Sch Med, Ctr Diabet Res, Winston Salem, NC 27101 USA Univ Manchester, Ctr Genet & Genom Versus Arthrit, Ctr Musculoskeletal Res, Div Musculoskeletal & Dermatol Sci, Manchester, Lancs, England Manchester Univ NHS Fdn Trust, NIHR Manchester Biomed Res Ctr, Manchester, Lancs, England Genentech Inc, San Francisco, CA 94080 USA Pfizer Worldwide Res, Internal Med Res Unit, Cambridge, MA USA UNAM, Dept Med Genom & Toxicol Ambiental, Inst Invest Biomed, Ciudad De Mexico, Mexico Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA Korea Univ, Inst Data Sci, Seoul, South Korea Ochsner Hlth, Div Acad, New Orleans, LA USA Vertex Pharmaceut Ltd, Oxford, England Univ Exeter, Exeter Ctr Excellence Diabet ExCE, Exeter Med Sch, Exeter, Devon, England Ibusuki Kozenkai Hosp, Ibusuki, Japan Regeneron Genet Ctr, Tarrytown, NY USA Univ Chicago, Inst Populat & Precis Hlth IPPH, Biol Sci Div, Chicago, IL 60637 USA Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England Toranomon Gen Hosp, Tokyo, Japan |
| Keywords | GENOME-WIDE ASSOCIATION METABOLIC SYNDROME PROVIDES INSIGHTS RISK SCORES INSULIN VARIANTS SUSCEPTIBILITY ARCHITECTURE METAANALYSIS EXPRESSION |
| Issue Date | May-2022 |
| Publisher | NATURE GENETICS |
| Abstract | We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations. |
| URI | http://hdl.handle.net/20.500.11897/643355 |
| ISSN | 1061-4036 |
| DOI | 10.1038/s41588-022-01058-3 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
