| Title | Association of high BMI with subclinical hypothyroidism in young, first-episode and drug-naive patients with major depressive disorder: a large-scale cross-sectional study |
| Authors | Kang, Chuanyi Liu, Jiacheng Zheng, Yue Wang, Xiaohong Yang, Liying Qiu, Siyu Zhao, Ying Lackey, Blake N. Wu, Hanjing Emily Zhao, Na Zhang, Xiangyang |
| Affiliation | Harbin Med Univ, Dept Psychiat, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China Peking Univ, Inst Mental Hlth, Hosp 6, Beijing, Peoples R China Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China Peking Univ, NHC Key Lab Mental Hlth, Beijing, Peoples R China Harbin Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China Harbin Med Univ, Dept Lab, Affiliated Hosp 4, Harbin, Heilongjiang, Peoples R China Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| Keywords | BODY-MASS INDEX THYROID-FUNCTION SEX-DIFFERENCES OBESE CHILDREN RISK-FACTORS AUTOIMMUNITY POPULATION HORMONE ANXIETY SYMPTOMS |
| Issue Date | May-2022 |
| Publisher | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE |
| Abstract | Thyroid dysfunction is known to be associated with obesity, but the reliability of this relationship is easily affected by drug treatment, age, and subclinical hypothyroidism (SCH) with no apparent symptoms. Our research aims to compare obese and overweight BMI ranges with SCH and without SCH in a large sample of young, first-episode and drug-naive (FEDN) patients with major depressive disorder (MDD), which has received little systemic investigation. A total of 1289 FEDN MDD young outpatients were recruited for this study. Serum thyroid function and lipid level parameters were measured; HAMD and PANSS scales were used to assess patients' depression and positive symptoms. A self-administered questionnaire collected other clinical and demographic data. The prevalence of SCH in FEDN MDD young patients was 58.26%. Compared to patients without SCH, the patients with SCH had a more prolonged illness duration, higher BMI levels, increased prevalence of overweight and obesity, higher HAMD score and PANSS-positive symptom scores, higher levels of TG, TC, LDL-C, and lower levels of HDL-C. Further logistic regression indicated that overweight BMI, obese BMI, illness duration, HAMD score, HDL-C, and TC were significantly associated with SCH. Our results indicate that obesity and overweight may be associated with SCH in young, FEDN MDD patients. The importance of regular thyroid function assessment in young FEDN MDD patients with high BMI should be taken into account. |
| URI | http://hdl.handle.net/20.500.11897/643308 |
| ISSN | 0940-1334 |
| DOI | 10.1007/s00406-022-01415-7 |
| Indexed | SCI(E) |
| Appears in Collections: | 第六医院 |
