| Title | Ceramide metabolism mediates the impaired glucose homeostasis following short-term black carbon exposure: A targeted lipidomic analysis |
| Authors | Xu, Yifan Chen, Xi Han, Yiqun Chen, Wu Wang, Teng Gong, Jicheng Fan, Yunfei Zhang, Hanxiyue Zhang, Lina Li, Haonan Wang, Qi Yao, Yuan Xue, Tao Wang, Junxia Qiu, Xinghua Que, Chengli Zheng, Mei Zhu, Tong |
| Affiliation | Peking Univ, Ctr Environm & Hlth, Coll Environm Sci & Engn, BIC ESAT & SKL ESPC, Beijing, Peoples R China Shenzhen Inst Bldg Res Co Ltd, Hebei Technol Innovat Ctr Human Settlement Green, Xiongan, Peoples R China Imperial Coll London, MRC Ctr Environm & Hlth, Environm Res Grp, London, England Shi Cha Hai Community Hlth Serv Ctr, Beijing, Peoples R China Peking Univ, Sch Publ Hlth, Beijing, Peoples R China Peking Univ, Peking Univ Hosp 1, Beijing, Peoples R China |
| Keywords | AMBIENT AIR-POLLUTION INSULIN-RESISTANCE PLASMA SPHINGOLIPIDS INFLAMMATION TISSUE MICE |
| Issue Date | 10-Jul-2022 |
| Publisher | SCIENCE OF THE TOTAL ENVIRONMENT |
| Abstract | Background: Ambient particulate matter (PM), especially its carbonaceous composition black carbon (BC) increases cardiometabolic risks, yet the underlying mechanisms are incompletely understood. Ceramides (Cer; a class of sphingolipids) are biological intermediates in glucose metabolism. Objectives: To explore whether Cer metabolism mediates impaired glucose homeostasis following short-term PM exposure. Methods: In a panel study in Beijing, China, 112 participants were followed-up between 2016 and 2017. Targeted lipidomic analyses quantified 26 sphingolipids in 387 plasma samples. Ambient BC and PM with aerodynamic diameter <= 2.5 mu m (PM2.5) were continuously monitored in a station. We examined the associations of sphingolipid levels with average BC and PM2.5 concentrations 1-14 days before clinical visits using linear mixed-effects models, and explored the mediation effects of sphingolipids on PM-associated fasting blood glucose (FBG) difference using mediation analyses. Results: Increased levels of FBG and multiple sphingolipids in Cer metabolic pathways were associated with BC exposure in 1-14-day time window, but not with PM2.5 exposure. For each 10 mu g/m(3) increase in the average BC concentration 1-14 days before the clinical visits, species in the Cer C24:1 pathway (Cer, dihydroceramide, hexosylceramide, lactosylceramide, and sphingomyelin C24:1) increased in levels ranging from 11.8% (95% confidence interval [CI]: -6.2-33.2) to 48.7% (95% CI: 8.8-103.4), as did the Cer C16:0, C18:0, and C20:0 metabolic pathway species, ranging from 3.2% (95% CI:-5.6-12.9) to 32.4% (95% CI: 7.0-63.8), respectively. The Cer C24:1 metabolic pathway species mediated 6.5-25.5% of the FBG increase associated with BC exposure in 9-day time window. The Cer C16:0, C18:0, and C20:0 metabolic pathway species mediated 5.4-26.2% of the BC-associated FBG difference. Conclusions: In conclusion, Cermetabolism may mediate impaired glucose homeostasis following short-term BC exposure. The current findings are preliminary, which need to be corroborated by further studies. |
| URI | http://hdl.handle.net/20.500.11897/643071 |
| ISSN | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2022.154657 |
| Indexed | EI SCI(E) |
| Appears in Collections: | 环境科学与工程学院 公共卫生学院 第一医院 校医院 |
