| Title | Oxidation and Antioxidation of Natural Products in the Model Organism Caenorhabditis elegans |
| Authors | Zhu, An Zheng, Fuli Zhang, Wenjing Li, Ludi Li, Yingzi Hu, Hong Wu, Yajiao Bao, Wenqiang Li, Guojun Wang, Qi Li, Huangyuan |
| Affiliation | Fujian Med Univ, Sch Basic Med Sci, Minist Educ Gastrointestinal Canc, Key Lab, Fuzhou 350108, Peoples R China Fujian Med Univ, Sch Publ Hlth, Dept Prevent Med, Fuzhou 350108, Peoples R China Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China Peking Univ, Sch Publ Hlth, Dept Toxicol, Beijing 100191, Peoples R China Fujian Med Univ, Sch Basic Med Sci, Dept Pathogen Biol, Fuzhou 350108, Peoples R China Capital Med Univ, Sch Publ Hlth, Beijing 100069, Peoples R China Peking Univ, Key Lab State Adm Tradit Chinese Med Compatibil T, Beijing 100191, Peoples R China Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China Fujian Med Univ, Sch Publ Hlth, Key Lab Environm & Hlth, Fuzhou 350108, Peoples R China Fujian Med Univ, Sch Publ Hlth, Fujian Prov Key Lab Environm Factors & Canc, Fuzhou 350108, Peoples R China |
| Keywords | LIFE-SPAN EXTENSION C.-ELEGANS STRESS RESISTANCE LIPID-PEROXIDATION PROTEIN OXIDATION DNA-DAMAGE REPRODUCTIVE TOXICITY SUPEROXIDE-DISMUTASE GENE-EXPRESSION FACTOR SKN-1 |
| Issue Date | Apr-2022 |
| Publisher | ANTIOXIDANTS |
| Abstract | Natural products are small molecules naturally produced by multiple sources such as plants, animals, fungi, bacteria and archaea. They exert both beneficial and detrimental effects by modulating biological targets and pathways involved in oxidative stress and antioxidant response. Natural products' oxidative or antioxidative properties are usually investigated in preclinical experimental models, including virtual computing simulations, cell and tissue cultures, rodent and nonhuman primate animal models, and human studies. Due to the renewal of the concept of experimental animals, especially the popularization of alternative 3R methods for reduction, replacement and refinement, many assessment experiments have been carried out in new alternative models. The model organism Caenorhabditis elegans has been used for medical research since Sydney Brenner revealed its genetics in 1974 and has been introduced into pharmacology and toxicology in the past two decades. The data from C. elegans have been satisfactorily correlated with traditional experimental models. In this review, we summarize the advantages of C. elegans in assessing oxidative and antioxidative properties of natural products and introduce methods to construct an oxidative damage model in C. elegans. The biomarkers and signaling pathways involved in the oxidative stress of C. elegans are summarized, as well as the oxidation and antioxidation in target organs of the muscle, nervous, digestive and reproductive systems. This review provides an overview of the oxidative and antioxidative properties of natural products based on the model organism C. elegans. |
| URI | http://hdl.handle.net/20.500.11897/642489 |
| DOI | 10.3390/antiox11040705 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
