| Title | Boron encapsulated in a liposome can be used for combinational neutron capture therapy |
| Authors | Li, Jiyuan Sun, Qi Lu, Chuanjie Xiao, Han Guo, Zhibin Duan, Dongban Zhang, Zizhu Liu, Tong Liu, Zhibo |
| Affiliation | Peking Univ, Radiochem & Radiat Chem Key Lab Fundamental Sci, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China Peking Univ, Tsinghua Univ, Ctr Life Sci, Beijing 100871, Peoples R China Univ Chinese Acad Sci Beijing, Beijing 100049, Peoples R China Beijing Nucl Ind Hosp, Beijing 100045, Peoples R China Beijing Capture Tech Co Ltd, Beijing 102413, Peoples R China |
| Issue Date | 19-Apr-2022 |
| Publisher | NATURE COMMUNICATIONS |
| Abstract | Boron neutron capture therapy is a type of cancer therapy but is associated with insufficient boron delivery and with poor biocompatibility. Here, the authors constructed boronated lipids to generate - boronsome - and show the system can reduce tumour growth. Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due to binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for combinational BNCT and chemotherapy. Theoretical simulations and experimental approaches illustrate high stability of boronsome. Then positron emission tomography (PET) imaging with Cu-64 labelled boronsome reveals high-specific tumour accumulation and long retention with a clear irradiation background. In particular, we show the suppression of tumour growth treated with boronsome with neutron irradiation and therapeutic outcomes are further improved by encapsulation of chemotherapy drugs, especially with PARP1 inhibitors. In sum, boronsome may be an efficient agent for concurrent chemoradiotherapy with theranostic properties against malignancies. |
| URI | http://hdl.handle.net/20.500.11897/642479 |
| DOI | 10.1038/s41467-022-29780-w |
| Indexed | SCI(E) |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ 生命科学学院 |
